A process model account of the role of dopamine in intertemporal choice

被引:8
|
作者
Soutschek, Alexander [1 ]
Tobler, Philippe N. [2 ,3 ]
机构
[1] Ludwig Maximilian Univ Munich, Dept Psychol, Munich, Germany
[2] Univ Zurich, Zurich Ctr Neuroecon, Dept Econ, Zurich, Switzerland
[3] Univ Zurich, Swiss Fed Inst Technol Zurich, Neurosci Ctr Zurich, Zurich, Switzerland
来源
ELIFE | 2023年 / 12卷
基金
瑞士国家科学基金会;
关键词
delay discounting; drift diffusion model; reward; proximity; dopamine; amisulpride; Human; ANTAGONIST; MODULATION; REWARD; AMISULPRIDE; MOTIVATION; RECEPTORS; PREDICTS; CORTEX; TIME;
D O I
10.7554/eLife.83734
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Theoretical accounts disagree on the role of dopamine in intertemporal choice and assume that dopamine either promotes delay of gratification by increasing the preference for larger rewards or that dopamine reduces patience by enhancing the sensitivity to waiting costs. Here, we reconcile these conflicting accounts by providing empirical support for a novel process model according to which dopamine contributes to two dissociable components of the decision process, evidence accumulation and starting bias. We re-analyzed a previously published data set where intertemporal decisions were made either under the D2 antagonist amisulpride or under placebo by fitting a hierarchical drift diffusion model that distinguishes between dopaminergic effects on the speed of evidence accumulation and the starting point of the accumulation process. Blocking dopaminergic neurotransmission not only strengthened the sensitivity to whether a reward is perceived as worth the delay costs during evidence accumulation (drift rate) but also attenuated the impact of waiting costs on the starting point of the evidence accumulation process (bias). In contrast, re-analyzing data from a D1 agonist study provided no evidence for a causal involvement of D1R activation in intertemporal choices. Taken together, our findings support a novel, process-based account of the role of dopamine for cost-benefit decision making, highlight the potential benefits of process-informed analyses, and advance our understanding of dopaminergic contributions to decision making.
引用
收藏
页数:20
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