Modification, 3D printing process and application of sodium alginate based hydrogels in soft tissue engineering: A review

被引：120
作者：
Wei, Qinghua [1 ,2 ]
Zhou, Jiayi [1 ,2 ]
An, Yalong [1 ,2 ]
Li, Mingyang [1 ,2 ]
Zhang, Juan [1 ,2 ]
Yang, Sheng [3 ]
机构：
[1] Northwestern Polytech Univ, Sch Mech Engn, Xian 710072, Peoples R China
[2] Northwestern Polytech Univ, Innovat Ctr NPU Chongqing, Chongqing 400000, Peoples R China
[3] Univ Guelph, Sch Engn, Guelph, ON N1G 2W1, Canada
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2023年 / 232卷
基金：
中国国家自然科学基金;
关键词：
Sodium alginate; Modification; 3D bioprinting; OXIDIZED ALGINATE; MYOCARDIAL-INFARCTION; BIOLOGICAL-PROPERTIES; SEQUENTIAL DELIVERY; STEM-CELLS; IN-VITRO; SCAFFOLDS; GELATIN; BIOMATERIALS; FABRICATION;
D O I：
10.1016/j.ijbiomac.2023.123450
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sodium alginate (SA) is an inexpensive and biocompatible biomaterial with fast and gentle crosslinking that has been widely used in biological soft tissue repair/regeneration. Especially with the advent of 3D bioprinting technology, SA hydrogels have been applied more deeply in tissue engineering due to their excellent printability. Currently, the research on material modification, molding process and application of SA-based composite hydrogels has become a hot topic in tissue engineering, and a lot of fruitful results have been achieved. To better help readers have a comprehensive understanding of the development status of SA based hydrogels and their molding process in tissue engineering, in this review, we summarized SA modification methods, and provided a comparative analysis of the characteristics of various SA based hydrogels. Secondly, various molding methods of SA based hydrogels were introduced, the processing characteristics and the applications of different molding methods were analyzed and compared. Finally, the applications of SA based hydrogels in tissue engineering were reviewed, the challenges in their applications were also analyzed, and the future research directions were pro-spected. We believe this review is of great helpful for the researchers working in biomedical and tissue engineering.
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页数：31
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