Natural Bioactive Molecules as Neuromedicines for the Treatment/Prevention of Neurodegenerative Diseases

被引:27
作者
Babazadeh, Afshin [1 ]
Vahed, Fereshteh Mohammadi [1 ]
Liu, Qi [5 ,6 ]
Siddiqui, Shahida Anusha [2 ,3 ]
Kharazmi, Mohammad Saeed [4 ]
Jafari, Seid Mahdi [7 ,8 ,9 ]
机构
[1] Macquarie Univ, Fac Med Hlth & Human Sci, Ctr Motor Neuron Dis Res, Macquarie Med Sch, Sydney, NSW 2109, Australia
[2] Tech Univ Munich, Campus Straubing Biotechnol & Sustainabil, D-94315 Straubing, Germany
[3] German Inst Food Technol DIL eV, D-49610 Quankenbruck, Germany
[4] Univ Calif Riverside, Fac Med, Riverside, CA 92679 USA
[5] Yangzhou Univ, Inst Translat Med, Coll Med, Yangzhou 225009, Jiangsu, Peoples R China
[6] Yangzhou Univ, Jiangsu Key Lab Integrated Tradit Chinese & Weste, Yangzhou 225009, Jiangsu, Peoples R China
[7] Gorgan Univ Agr Sci & Nat Resources, Dept Food Mat & Proc Design Engn, Gorgan 4913815739, Golestan, Iran
[8] Univ Vigo, Dept Analyt Chem & Food Sci, Fac Sci, Nutr & Bromatol Grp, E-32004 Orense, Spain
[9] Hebei Agr Univ, Coll Food Sci & Technol, Baoding 071001, Peoples R China
来源
ACS OMEGA | 2023年 / 8卷 / 04期
关键词
POLYUNSATURATED FATTY-ACIDS; ALZHEIMERS-DISEASE; OXIDATIVE-STRESS; ESSENTIAL OIL; PARKINSONS-DISEASE; DIABETES-MELLITUS; VITAMIN-E; PHENOLIC-COMPOUNDS; ALPHA-TOCOPHEROL; COGNITIVE DEFICITS;
D O I
10.1021/acsomega.2c06098
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The brain is vulnerable to different types of stresses, particularly oxidative stress as a result of oxygen requirements/utilization in the body. Large amounts of unsaturated fatty acids present in the brain increase this vulnerability. Neurodegenerative diseases (NDDs) are brain disorders that are characterized by the gradual loss of specific neurons and are attributed to broad evidence of cell-level oxidative stress. The accurate characterization of neurological disorders relies on several parameters along with genetics and environmental risk factors, making therapies less efficient to fight NDDs. On the way to tackle oxidative damage and discover efficient and safe therapies, bioactives are at the edge of NDD science. Naturally occurring bioactive compounds such as polyphenols, carotenoids, essential fatty acids, phytosterols, essential oils, etc. are particularly of interest owing to their potent antioxidant and anti-inflammatory activities, and they offer lots of brain-health-promoting features. This Review focuses on probing the neuroefficacy and bioefficacy of bioactives and their role in supporting relatively low antioxidative and low regenerative capacities of the brain, neurogenesis, neuroprotection, and ameliorating/treating NDDs.
引用
收藏
页码:3667 / 3683
页数:17
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