Systematic Review of Endocan as a Potential Biomarker of COVID-19

被引：18
作者：
Khalaji, Amirmohammad [1 ,2 ]
Amirkhani, Nikan [1 ]
Sharifkashani, Sourena [1 ]
Peiman, Soheil [3 ]
Behnoush, Amir Hossein [1 ,2 ,4 ]
机构：
[1] Univ Tehran Med Sci, Sch Med, Tehran, Iran
[2] Univ Tehran Med Sci, Endocrinol & Metab Populat Sci Inst, Noncommunicable Dis Res Ctr, Tehran, Iran
[3] AdventHlth Orlando Hosp, Dept Internal Med, Orlando, FL USA
[4] Univ Tehran Med Sci, Sch Med, Poursina St,Keshavarz Blvd, Tehran 1417613151, Iran
来源：
ANGIOLOGY | 2024年 / 75卷 / 02期
关键词：
endocan; COVID-19; endothelial cell-specific molecule-1; ESM-1; systematic review; CARDIOVASCULAR EVENTS; HYPERTENSION; SULFATE; DISEASE;
D O I：
10.1177/00033197231152941
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Since the start of the coronavirus disease 2019 (COVID-19) pandemic, several biomarkers have been proposed to assess the diagnosis and prognosis of this disease. The present systematic review evaluated endocan (a marker of endothelial cell damage) as a potential diagnostic and prognostic biomarker for COVID-19. PubMed, Scopus, Web of Science, and Embase were searched for studies comparing circulating endocan levels between COVID-19 cases and controls, and/or different severities/complications of COVID-19. Eight studies (686 individuals) were included, from which four reported significantly higher levels of endocan in COVID-19 cases compared with healthy controls. More severe disease was also associated with higher endocan levels in some of the studies. Studies reported higher endocan levels in patients who died from COVID-19, were admitted to an intensive care unit, and had COVID-19-related complications. Endocan also acted as a diagnostic and prognostic biomarker with different cut-offs. In conclusion, endocan could be a novel diagnostic and prognostic biomarker for COVID-19. Further studies with larger sample sizes are warranted to evaluate this role of endocan.
引用
收藏
页码：107 / 115
页数：9
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