A berberine induced disassembly towards zwitterionic surfactant as mimicking cell membrane for light-scattering sensing and logic devices

被引：1

作者：

Feng, Da-Qian ^{[1
,2
]}

Teng, Youjian ^{[1
,2
]}

Shi, Haiwen ^{[1
,2
]}

Liu, Guoliang ^{[1
,2
]}

机构：

[1] Yancheng Inst Technol, Sch Chem & Chem Engn, Yancheng 224051, Peoples R China

[2] Yancheng Inst Technol, Key Lab Adv Technol Environm Protect Jiangsu Prov, Yancheng 224051, Peoples R China

来源：

TALANTA | 2023年 / 255卷

基金：

中国国家自然科学基金;

关键词：

Bionic phosphate ester; Light-scattering; Self-assembly; Logic gate; Berberine; RESONANCE RAYLEIGH-SCATTERING; GOLD NANOPARTICLES; GEMINI SURFACTANTS; DNA; IONS; NANOCLUSTERS; BIOSENSOR; PROBE; ASSAY;

D O I：

10.1016/j.talanta.2023.124259

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A label-free light-scattering sensor for berberine determination was developed based on Gemini zwitterionic surfactant as logic devices. Amphiphilic phosphodiesters quaternary ammonium nanoparticles (PQANPs) with bionic phosphate ester structure were selected as a model for mimicking cell membrane. PQANPs self-assembled and formed the micelle structure, emitting strong light-scattering signal. Interestingly, the addition of berberine induced remarkable decrease of light-scattering attribute to its interfering behavior of PQANPs aggregation. Disassembly of PQANPs could be triggered due to electrostatic interaction and hydrophobic force between PQANPs and berberine. The berberine attached to the PQANPs surface and generated nanocomposites, resulting in significant reduce of light-scattering signal. Hence, it generated a strong light-scattering signal variation ac-cording to the change of the concentration of target. Our proposed light-scattering on-off sensor could be applied for berberine detection with detection limit of 27 nM. Moreover, a logic gate system was constructed based on PQANPs sensor with berberine and the interfering substances as the inputs and the light-scattering intensity as an output, which could hold great potential application in future clinical diagnosis and drug analysis.

引用

页数：8