Depressive symptoms and mortality-findings from Helsinki birth cohort study

被引:8
作者
Eriksson, Mia D. [1 ,2 ,3 ,4 ]
Eriksson, Johan G. [1 ,2 ,3 ,5 ,6 ,7 ]
Korhonen, Paivi [8 ,9 ]
Koponen, Hannu [2 ,10 ]
Salonen, Minna K. [3 ,11 ]
Mikkola, Tuija M. [3 ,12 ]
Kajantie, Eero [11 ,13 ,14 ,15 ]
Wasenius, Niko S. [1 ,2 ,3 ]
von Bonsdorff, Mikaela [3 ,16 ,17 ]
Kautiainen, Hannu [3 ,18 ]
Laine, Merja K. [1 ,2 ,3 ]
机构
[1] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland
[2] Helsinki Univ Hosp, Helsinki, Finland
[3] Folkhalsan Res Ctr, Helsinki, Finland
[4] Univ Helsinki, Fac Med, Doctoral Programme Populat Hlth, Helsinki, Finland
[5] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynecol, Singapore, Singapore
[6] Natl Univ Singapore, Yong Loo Lin Sch Med, Human Potential Translat Res Programme, Singapore, Singapore
[7] ASTAR, Singapore Inst Clin Sci SICS, Singapore, Singapore
[8] Turku Univ Hosp, Turku, Finland
[9] Univ Turku, Turku, Finland
[10] Univ Helsinki, Dept Psychiat, Helsinki, Finland
[11] Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, Publ Hlth Promot Unit, Helsinki, Finland
[12] Univ Helsinki, Fac Med, Clinicum, Helsinki, Finland
[13] Oulu Univ Hosp, PEDEGO Res Unit, MRC Oulu, Oulu, Finland
[14] Univ Oulu, Oulu, Finland
[15] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway
[16] Univ Jyvaskyla, Gerontol Res Ctr, Jyvaskyla, Finland
[17] Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland
[18] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland
基金
芬兰科学院;
关键词
cohort studies; comorbidity; depression; depressive disorder; mortality; ALL-CAUSE MORTALITY; METABOLIC SYNDROME; EXCESS MORTALITY; RISK-FACTOR; INTERVENTION; METAANALYSIS; ASSOCIATION; INVENTORY; DISEASE; HEALTH;
D O I
10.1111/acps.13512
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background Individuals with depression and depressive symptoms have a higher mortality rate than non-depressed individuals. The increased comorbidity and mortality associated with depression has remained largely unexplained. The underlying pathophysiological differences between depressive subtypes, melancholic and non-melancholic, may provide some explanation to this phenomenon. Methods One thousand nine hundred and ninety five participants (mean age 61 years) from the Helsinki Birth Cohort Study were recruited for this prospective study and followed up for a mean of 14.1 years. Information regarding medical history, lifestyle, and biochemical parameters were obtained. Depressive symptoms were assessed using the Beck Depression Inventory. Standardized mortality ratios were calculated. Results Participants were followed up for a total of 28,044 person-years. The melancholic depressive group had an increased adjusted risk of mortality [HR 1.49 (95% CI: 1.02-2.20)] when compared to the non-depressive group. Comparing mortality to the whole population of Finland using standardized mortality ratios (SMR) both the non-melancholic [1.11 (95% CI: 0.85-1.44)] and melancholic depressive [1.26 (95% CI: 0.87-1.81)] groups had higher mortality than the non-depressive group [0.82 (95% CI: 0.73-0.93)]. Conclusions Melancholic depressive symptoms are most strongly related to a higher mortality risk.
引用
收藏
页码:175 / 185
页数:11
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