Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer

被引：9

作者：

Alsaiari, Shahad K. ^{[1
]}

Nadeef, Seba ^{[1
]}

Daristotle, John L. ^{[1
]}

Rothwell, William ^{[1
,2
]}

Du, Bujie ^{[1
]}

Garcia, Johnny ^{[1
]}

Zhang, Linzixuan ^{[3
]}

Sarmadi, Morteza ^{[1
]}

Forster, Timothy A. ^{[1
]}

Menon, Nandita ^{[1
]}

Lin, Stacey Qiaohui ^{[1
]}

Tostanoski, Lisa H. ^{[4
]}

Hachmann, Nicole ^{[4
]}

Wang, Erika Yan ^{[1
]}

Ventura, John D. ^{[4
]}

Barouch, Dan H. ^{[4
]}

Langer, Robert ^{[1
,3
]}

Jaklenec, Ana ^{[1
]}

机构：

[1] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[2] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[3] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[4] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Virol & Vaccine Res, Boston, MA 02215 USA

来源：

SCIENCE ADVANCES | 2024年 / 10卷 / 10期

关键词：

PATHOGEN RECOGNITION; SUBUNIT VACCINE; RESPONSES; AGONISTS; IMMUNE; INFECTION; ROLES;

D O I：

10.1126/sciadv.adj6380

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nanomaterials offer unique opportunities to engineer immunomodulatory activity. In this work, we report the Toll-like receptor agonist activity of a nanoscale adjuvant zeolitic imidazolate framework-8 (ZIF-8). The accumulation of ZIF-8 in endosomes and the pH-responsive release of its subunits enable selective engagement with endosomal Toll-like receptors, minimizing the risk of off-target activation. The intrinsic adjuvant properties of ZIF-8, along with the efficient delivery and biomimetic presentation of a severe acute respiratory syndrome coronavirus 2 spike protein receptor-binding domain trimer, primed rapid humoral and cell-mediated immunity in a dose-sparing manner. Our study offers insights for next-generation adjuvants that can potentially impact future vaccine development.

引用

页数：11

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