TFE-Facilitated Synthesis of Tetrahydropyridino[2,3-d]pyrimidine via Cascade [1,5]-Hydride Transfer/Cyclization

被引：1

作者：

Wei, Cong ^{[1
]}

Li, Yan ^{[1
]}

Yao, Xin ^{[1
]}

Zhang, Kui ^{[1
]}

Cai, Lingchao ^{[1
]}

机构：

[1] Nanjing Forestry Univ, Coll Chem Engn, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat Fo, Int Innovat Ctr Forest Chem & Mat,Jiangsu Prov Key, Nanjing 210037, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 24期

基金：

中国国家自然科学基金;

关键词：

C(SP(3))-H; FUNCTIONALIZATION; TRANSFORMATIONS; HETEROCYCLES; ABIRATERONE; TRAPIDIL; DRUGS; ACID; RING;

D O I：

10.1021/acs.joc.3c02004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient fluorinated alcohol-driven cascade [1,5]-hydride transfer/cyclization between o-amino pyridyl aldehydes and primary amines has been developed. This unique transformation enabled an array of tetrahydropyridino-[2,3-d]-pyrimidine construction. Furthermore, the encouraging antifungal activity of Thanatephorus cucumeris was demonstrated by this tetrahydropyridino-[2,3-d]-pyrimidine core structure.

引用

页码：17144 / 17154

页数：11

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