Is the suppression of CD36 a promising way for atherosclerosis therapy?

被引：2
|
作者：
Wen, Shi-Yuan [1 ]
Zhi, Xiaoyan [1 ]
Liu, Hai-Xin [2 ]
Wang, Xiaohui [1 ]
Chen, Yan-Yan [3 ]
Wang, Li [1 ]
机构：
[1] Shanxi Med Univ, Coll Basic Med Sci, Taiyuan, Peoples R China
[2] Shanxi Univ Chinese Med, Sch Tradit Chinese Mat Med, Taiyuan, Peoples R China
[3] Jiangsu Univ, Sch Med, Zhenjiang, Peoples R China
来源：
BIOCHEMICAL PHARMACOLOGY | 2024年 / 219卷
关键词：
CD36; Drug therapy; Atherosclerosis; Lipid metabolism; FOAM-CELL-FORMATION; LOW-DENSITY-LIPOPROTEIN; FATTY-ACID UPTAKE; NLRP3 INFLAMMASOME ACTIVATION; OXIDIZED LDL; LIPID-ACCUMULATION; DOWN-REGULATION; ATTENUATES ATHEROSCLEROSIS; CHOLESTEROL EFFLUX; APOE(-/-) MICE;
D O I：
10.1016/j.bcp.2023.115965
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Atherosclerosis is the main underlying pathology of many cardiovascular diseases and is marked by plaque formation in the artery wall. It has posed a serious threat to the health of people all over the world. CD36 acts as a significant regulator of lipid homeostasis, which is closely associated with the onset and progression of atherosclerosis and may be a new therapeutic target. The abnormal overexpression of CD36 facilitates lipid accumulation, foam cell formation, inflammation, endothelial apoptosis, and thrombosis. Numerous natural products and lipid-lowering agents are found to target the suppression of CD36 or inhibit the upregulation of CD36 to prevent and treat atherosclerosis. Here, the structure, expression regulation and function of CD36 in atherosclerosis and its related pharmacological therapies are reviewed. This review highlights the importance of drugs targeting CD36 suppression in the treatment and prevention of atherosclerosis, in order to develop new therapeutic strategies and potential anti-atherosclerotic drugs both preclinically and clinically.
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页数：16
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