Prevalence of Hepatitis C Viral Infection among Diabetes Mellitus Patients in Qassim Region, Saudi Arabia

被引:0
作者
Aldubaie, Muneerah Hamad [1 ,2 ]
Suryavamshi, Prarthana M. [1 ]
Irfan, Uma M. [3 ]
Al-Hamed, Hamad A. [4 ]
Almogbel, Turki Abdullah [5 ]
Almatroudi, Ahmad [1 ]
Alrumaihi, Faris [1 ]
Allemailem, Khaled [1 ]
机构
[1] Qassim Univ, Coll Appl Med Sci, Dept Med Labs, Buraydah 51452, Saudi Arabia
[2] Dr Sulaiman Al Habib Med Grp, Dept Lab, Riyadh 11635, Saudi Arabia
[3] Case Western Reserve Univ, Sch Dent Med, Cleveland, OH 44106 USA
[4] King Fahd Specialist Hosp, Dept Lab & Blood Bank, Buraydah 52211, Saudi Arabia
[5] King Fahd Specialist Hosp, Diabet Ctr, Buraydah 52211, Saudi Arabia
关键词
Hepatitis C Virus; Viral Load; Diabetes Mellitus Type I; Diabetes Mellitus Type II; Qassim Region; VIRUS-INFECTION; INSULIN-RESISTANCE; HEPATOCELLULAR-CARCINOMA; INCREASED RISK; ASSOCIATION; HCV; EPIDEMIOLOGY; RIBAVIRIN; CIRRHOSIS; THERAPY;
D O I
10.22207/JPAM.17.3.37
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The worldwide prevalence of Diabetes Mellitus (DM) associated with Hepatitis C Virus (HCV) infection are reported with higher rates of morbidity and mortality. The frequency of HCV is approximately 3-4 million cases each year and in parallel the incidence of DM is increasing alarmingly. World Health Organization (WHO) has specified that DM will be the 7th leading cause of mortality by 2030. The increasing association between HCV and DM has been indicated by some significant reports recently. HCV infection leads to hepatic steatosis and rapid insulin resistance, which in turn upsurges the risk factors for hepatic fibrosis and hepatocellular carcinoma. This study is designed to examine the association between HCV and DM, and different risk factors associated with HCV infection in Qassim region, Kingdom of Saudi Arabia (KSA). A total of 634 blood samples were obtained from diabetic and non-diabetic patients. These blood samples were first screened for HCV infection by enzyme-linked immunosorbent assay (ELISA) and positive samples were again confirmed by TaqMan HCV quantitative test and the viral load in different samples was estimated. The HCV prevalence was identified as 2.5% in diabetic patients with a positive association between HCV and DM (RR= 1.24, OR= 1.77) which is not significant statistically. However, the HCV prevalence among diabetic females was significantly different from males (p<0.05). The behavioural factors had no significant impact to acquire HCV infection. This study indicated a positive association between HCV and DM. Gender was an association factor in the HCV and DM status. Further studies with larger sample size is significant to properly assess the temporal relationship between HCV and DM.
引用
收藏
页码:1722 / 1736
页数:15
相关论文
共 60 条
[1]   Epidemiology of Viral Hepatitis in Saudi Arabia: Are We Off the Hook? [J].
Abdo, Ayman A. ;
Sanai, Faisal M. ;
Al-Faleh, Faleh Z. .
SAUDI JOURNAL OF GASTROENTEROLOGY, 2012, 18 (06) :349-357
[2]  
Agbecha A, 2017, J SCI SOC, V44, P100, DOI [10.4103/jss.JSS_25_17, DOI 10.4103/JSS.JSS_25_17]
[3]   Prevalence of type-2 diabetes in patients with hepatitis C and B virus infection in Jeddah, Saudi Arabia [J].
Akbar, DH ;
Siddique, AM ;
Ahmed, MM .
MEDICAL PRINCIPLES AND PRACTICE, 2002, 11 (02) :82-85
[4]   Hepatitis C Virus Infection at Primary Healthcare Level in Abha City, Southwestern Saudi Arabia: Is Type 2 Diabetes Mellitus an Associated Factor? [J].
Al Humayed, Suliman M. ;
Mahfouz, Ahmed A. ;
Awadalla, Nabil J. ;
Alsabaani, Abdullah A. .
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2018, 15 (11)
[5]  
Al-Nozha MM, 2004, SAUDI MED J, V25, P1603
[6]   Determination of HCV genotypes and viral loads in chronic HCV infected patients of Hazara Pakistan [J].
Ali, Amjad ;
Nisar, Muhammad ;
Ahmad, Habib ;
Saif, Nausheen ;
Idrees, Muhammad ;
Bajwa, Mohammad A. .
VIROLOGY JOURNAL, 2011, 8
[7]  
Ali Sobia S, 2007, J Ayub Med Coll Abbottabad, V19, P46
[8]  
AlKahtani AM, 2019, BIORXIV, DOI DOI 10.1101/603902
[9]   Seroprevalence of Viral Hepatitis B and C among Blood Donors in the Northern Region of Riyadh Province, Saudi Arabia [J].
Alqahtani, Saeed Mohammed ;
Alsagaby, Suliman A. ;
Mir, Shabir Ahmad ;
Alaidarous, Mohammed ;
Bin Dukhyil, Abdulaziz ;
Alshehri, Bader ;
Banawas, Saeed ;
Alturaiki, Wael ;
Alharbi, Naif Khalaf ;
Azad, Taif Anwar ;
Al Abdulmonem, Waleed .
HEALTHCARE, 2021, 9 (08)
[10]   Prevalence of diabetes mellitus in a Saudi community [J].
Alqurashi, Khalid A. ;
Aljabri, Khalid S. ;
Bokhari, Samia A. .
ANNALS OF SAUDI MEDICINE, 2011, 31 (01) :19-23