Enhancer RNAs: mechanisms in transcriptional regulation and functions in diseases

被引：18

作者：

Li, Qianhui ^{[1
]}

Liu, Xin ^{[1
]}

Wen, Jingtao ^{[1
]}

Chen, Xi ^{[1
]}

Xie, Bumin ^{[1
]}

Zhao, Yang ^{[1
]}

机构：

[1] Guangzhou Med Univ, Dept Gynecol Oncol, Guangzhou Key Lab Targeted Therapy Gynecol Oncol, Guangdong Prov Key Lab Major Obstet Dis,Dept Obste, 63 Duobao Rd, Guangzhou 510150, Guangdong, Peoples R China

来源：

CELL COMMUNICATION AND SIGNALING | 2023年 / 21卷 / 01期

关键词：

Enhancer; eRNAs; Transcription regulation; Diseases; HUMAN CELL-TYPES; SUPER-ENHANCERS; GENE-EXPRESSION; P-TEFB; INTERGENIC TRANSCRIPTION; CHROMATIN; PROMOTER; RECRUITMENT; ACTIVATION; LANDSCAPE;

D O I：

10.1186/s12964-023-01206-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In recent years, increasingly more non-coding RNAs have been detected with the development of high-throughput sequencing technology, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), small nucleolar RNAs (snoRNAs), and piwi-interacting RNA (piRNAs). The discovery of enhancer RNAs (eRNAs) in 2010 has further broadened the range of non-coding RNAs revealed. eRNAs are non-coding RNA molecules produced by the transcription of DNA cis-acting elements, enhancer fragments. Recent studies revealed that the transcription of eRNAs may be a biological marker responding to enhancer activity that can participate in the regulation of coding gene transcription. In this review, we discussed the biological characteristics of eRNAs, their functions in transcriptional regulation, the regulation factors of eRNAs production, and the research progress of eRNAs in different diseases.

引用

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