Imiquimod as Local Immunotherapy in the Management of Premalignant Cutaneous Conditions and Skin Cancer

被引：11

作者：

Garcia-Mouronte, Emilio ^{[1
]}

Berna-Rico, Emilio ^{[1
]}

de Nicolas-Ruanes, Belen ^{[1
]}

Azcarraga-Llobet, Carlos ^{[1
]}

Alonso-Martinez de Salinas, Luis ^{[1
]}

Bea-Ardebol, Sonia ^{[1
]}

机构：

[1] Hosp Univ Ramon & Cajal, Dermatol Dept, Madrid 28034, Spain

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 13期

关键词：

imiquimod; immunomodulation; immunotherapy; topical administration; skin neoplasms; actinic keratosis; basal cell carcinoma; melanoma; BASAL-CELL CARCINOMA; IMMUNE-RESPONSE MODIFIER; 5-PERCENT CREAM; TOPICAL IMIQUIMOD; DOUBLE-BLIND; PHOTODYNAMIC THERAPY; ACTINIC KERATOSES; MYCOSIS-FUNGOIDES; LENTIGO MALIGNA; PHASE-III;

D O I：

10.3390/ijms241310835

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cutaneous cancers are, by far, the most common malignant neoplasms of the human being. Due to the great array of clinical conditions, their worldwide increasing incidence and the steady ageing of the population, non-invasive treatments modalities that show a good clinical response, a proper benefit-risk ratio and cosmetic results are becoming increasingly important in the clinical setting. Imiquimod is a topically applied immunomodulator which is often used in the management of several premalignant and malignant cutaneous disorders. This article is a review of the current literature on its mechanism of action, pharmacokinetics, and therapeutical effects.

引用

页数：20

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