The microstructural evolution and mechanical properties of hot-rolled Al-Cu 2022 alloys were investigated to explore the effects of Zr addition and different homogenization procedures. Two-step low-temperature homogenization promoted a denser and finer distribution of Al3Zr particles in the Zr-containing alloy, which provided heterogeneous nucleation sites for & theta;& PRIME;& PRIME;/& theta;& PRIME; precipitates during the T7 treatment, increasing their number density. The Zr-containing T7-treated alloy exhibited a higher tensile strength than the base alloy. The Zr-containing alloy thermally exposed at 300 & DEG;C for 100 h still exhibited a higher tensile strength than the base alloy at both room and elevated temperatures. The Zr-containing alloy with two-step homogenization showed the highest yield strength of 157 and 114 MPa at 20 and 300 & DEG;C, respectively, which was 26 and 20% higher than that of the base alloy with conventional one-step homogenization. The strengthening mechanisms of the T7/T7A-treated alloys were quantitatively analyzed based on their microstructural characteristics. The predicted yield strengths agreed well with the experimentally measured values.