Expression and Correlation of MIF and ERK1/2 in Liver Cirrhosis and Hepatocellular Carcinoma Induced B

被引:2
|
作者
Jia, Dong [1 ]
Li, Bin [1 ]
Wang, Jun-Ke [1 ]
Wang, Pan [1 ]
Li, Chu-Yi [1 ]
Lu, Li-Xia [1 ]
Tian, Wen-Yan [1 ]
Yu, Xiao-Hui [1 ,2 ]
Zhang, Jiu-Cong [1 ,2 ]
Zheng, Ying [1 ]
机构
[1] 940th Hosp Joint Serv Logist Support Force Chinese, Dept Gastroenterol, Lanzhou, Peoples R China
[2] 940th Hosp Joint Serv Logist Support Force Peoples, Dept Gastroenterol, 333 Binhenan Rd, Lanzhou 730050, Peoples R China
来源
PHARMACOGENOMICS & PERSONALIZED MEDICINE | 2023年 / 16卷
关键词
MIF; MAPK signaling pathway; hepatitis B-induced liver cirrhosis; hepatocellular carcinoma;
D O I
10.2147/PGPM.S398976
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Objective: To detect expression and phosphorylation level of macrophage migration inhibitor (MIF) and extracellular-regulated kinases 1 and 2 (ERK1/2) in hepatitis B-induced liver cirrhosis (HBILC) and hepatocellular carcinoma (HCC) with a background of HBILC and analyze the correlation of MIF and ERK1/2 with HBILC and HCC. Methods: Twenty cases of normal liver tissues were collected as a control group, and 48 specimens of HBILC tissues and 48 specimens of HCC tissues were collected as the experimental group, which were assigned as the HBILC group and HCC group, respectively. All tissue specimens were processed into tissue chips. The expressions of MIF, ERK1/2, and their phosphorylated proteins were detected via immunohistochemistry, and MIF and ERK1/2 nucleic acid expressions were detected by in situ hybridiza-tion. The results were statistically analyzed using the chi-square test. Results: Proteins and nucleic acids of MIF and ERK1/2 presented low expression in the control group and high expression in the HBILC group and HCC group. MIF expression in the three groups was 25.0%, 75.0%, and 79.17%, respectively, while that of the nucleic acids was 25.0%, 70.83%, and 68.75%, respectively. Expression of ERK1/2 in the three groups was 40.0%, 60.42%, and 81.25%, respectively, and that of nucleic acids was 40.0%, 79.17%, and 77.08%. Expression of pERK1/2 was low in the control and HBILC group and high in the HCC group. Expression of pERK1/2 in the three groups was 20%, 45.83%, and 75%, respectively. Expression of pERK1/2 in the HCC group was significantly different from that in the HBILC and control group (P<0.05), but the difference between the HBILC group and control group was not statistically significant (P>0.05). Conclusion: Occurrence and development of HBILC and HCC are not only related to the high expression of MIF but also closely related to the activation of the ERK1/2 signaling pathway.
引用
收藏
页码:381 / 388
页数:8
相关论文
共 50 条
  • [21] Correlation between CT features and liver function and p53 expression in hepatitis, cirrhosis and hepatocellular carcinoma
    Hu, Yahui
    Wu, Jing
    Li, Sha
    Zhao, Xiaoxiao
    ONCOLOGY LETTERS, 2018, 16 (04) : 4297 - 4302
  • [22] Increased Expression of Claudin-1 and Claudin-7 in Liver Cirrhosis and Hepatocellular Carcinoma
    Holczbauer, Agnes
    Gyoengyoesi, Benedek
    Lotz, Gabor
    Toerzsoek, Peter
    Kaposi-Novak, Pal
    Szijarto, Attila
    Tatrai, Peter
    Kupcsulik, Peter
    Schaff, Zsuzsa
    Kiss, Andras
    PATHOLOGY & ONCOLOGY RESEARCH, 2014, 20 (03) : 493 - 502
  • [23] Expression level of glutamine synthetase is increased in hepatocellular carcinoma and liver tissue with cirrhosis and chronic hepatitis B
    Long, Jiang
    Wang, Huaguang
    Lang, ZhenWei
    Wang, Tailing
    Long, Mei
    Wang, BaoEn
    HEPATOLOGY INTERNATIONAL, 2011, 5 (02) : 698 - 706
  • [24] Expression level of glutamine synthetase is increased in hepatocellular carcinoma and liver tissue with cirrhosis and chronic hepatitis B
    Jiang Long
    Huaguang Wang
    ZhenWei Lang
    Tailing Wang
    Mei Long
    BaoEn Wang
    Hepatology International, 2011, 5 : 698 - 706
  • [25] Tensin4 is upregulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma
    Chan, Lo-Kong
    Chiu, Yung-Tuen
    Sze, Karen Man-Fong
    Ng, Irene Oi-Lin
    ONCOTARGET, 2015, 6 (25)
  • [26] LPS-Induced G-CSF Expression in Macrophages Is Mediated by ERK2, but Not ERK1
    Chang, Shwu-Fen
    Lin, Shih-Shan
    Yang, Hui-Ching
    Chou, Yuan-Yi
    Gao, Jhen-I
    Lu, Shao-Chun
    PLOS ONE, 2015, 10 (06):
  • [27] N-glycomic changes in hepatocellular carcinoma patients with liver cirrhosis induced by hepatitis B virus
    Liu, Xue-En
    Desmyter, Liesbeth
    Gao, Chun-Fang
    Laroy, Wouter
    Dewaele, Sylviane
    Vanhooren, Valerie
    Wang, Ling
    Zhuang, Hui
    Callewaert, Nico
    Libert, Claude
    Contreras, Roland
    Chen, Cuiying
    HEPATOLOGY, 2007, 46 (05) : 1426 - 1435
  • [28] Stromal expression of microRNA-21 and activation of Erk1/2 in papillary thyroid carcinoma
    Sugishita, Yoshiyuki
    CANCER SCIENCE, 2021, 112 : 646 - 646
  • [29] IFITM3 upregulates c-myc expression to promote hepatocellular carcinoma proliferation via the ERK1/2 signalling pathway
    Min, Jiaqi
    Hu, Junwen
    Luo, Chen
    Zhu, Jinfeng
    Zhao, Jiefeng
    Zhu, Zhengming
    Wu, Linquan
    Yuan, Rongfa
    BIOSCIENCE TRENDS, 2019, 13 (06) : 523 - 529
  • [30] Downregulation of secreted clusterin potentiates the lethality of sorafenib in hepatocellular carcinoma in association with the inhibition of ERK1/2 signals
    Zhong, Jingtao
    Yu, Xiaoming
    Dong, Xiaofeng
    Lu, Hong
    Zhou, Wuyuan
    Li, Lei
    Li, Zhongchao
    Sun, Pengfei
    Shi, Xuetao
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2018, 41 (05) : 2893 - 2900