Synthesis and conformational studies of hyperbranched-core star polymers with poly(?-benzyl-L-glutamate) arms

被引：2
|
作者：
Barratt, Claire M. [1 ]
Haraniya, Tejaswini K. [1 ]
Iwamasa, Sofie J. [2 ]
Yun, Justin J. [1 ]
Desyatkin, Victor G. [1 ]
Wilcox, Kathryn G. [1 ]
Morozova, Svetlana A. [1 ]
Rodionov, Valentin O. [1 ]
机构：
[1] Case Western Reserve Univ, Dept Macromol Sci & Engn, 2100 Adelbert Rd, Cleveland Hts, OH 44106 USA
[2] Case Western Reserve Univ, Dept Chem & Biomol Engn, 2100 Adelbert Rd, Cleveland Hts, OH 44106 USA
来源：
EUROPEAN POLYMER JOURNAL | 2023年 / 186卷
基金：
美国国家科学基金会;
关键词：
CuAAC; Step -growth polymerization; Polypeptides; Star polymers; Circular dichroism; -Helix; CIRCULAR-DICHROISM; SECONDARY STRUCTURE; POLYPEPTIDES; PROTONATION; HELIX; SEQUENCES; SOLVENTS;
D O I：
10.1016/j.eurpolymj.2023.111859
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A general methodology for the synthesis of star polymers with large number of polypeptide arms is described. The synthesis is based on the arm-first step-growth polymerization of bifunctional macromonomers by coppercatalyzed azide-alkyne cycloaddition. Star polymers with up to 18 poly-gamma-benzyl-L-glutamate (PBLG) arms have been synthesized and characterized. It is shown that the preferred secondary structure of PBLG is significantly affected by the degree of chain packing/crowding.
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页数：5
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