Qualitative and Quantitative Magnetic Resonance Imaging Phenotypes May Predict CDKN2A/B Homozygous Deletion Status in Isocitrate Dehydrogenase-Mutant Astrocytomas: A Multicenter Study

被引:21
作者
Park, Yae Won [1 ,2 ,3 ]
Park, Ki Sung [4 ]
Park, Ji Eun [5 ]
Ahn, Sung Soo [1 ,2 ,3 ]
Park, Inho [6 ,7 ]
Kim, Ho Sung [5 ]
Chang, Jong Hee [8 ]
Lee, Seung-Koo [1 ,2 ,3 ]
Kim, Se Hoon [9 ,10 ]
机构
[1] Yonsei Univ, Res Inst Radiol Sci, Coll Med, Seoul, South Korea
[2] Yonsei Univ, Ctr Clin Imaging Data Sci, Coll Med, Seoul, South Korea
[3] Yonsei Univ, Dept Radiol, Coll Med, Seoul, South Korea
[4] Pohang Univ Sci & Technol, Dept Mech Engn, Pohang, South Korea
[5] Ulsan Univ, Dept Radiol, Coll Med, Seoul, South Korea
[6] Yonsei Univ, Gangnam Severance Hosp, Ctr Precis Med, Coll Med, Seoul, South Korea
[7] Yonsei Univ, Gangnam Severance Hosp, Dept Pathol, Coll Med, Seoul, South Korea
[8] Yonsei Univ, Dept Neurosurg, Coll Med, Seoul, South Korea
[9] Yonsei Univ, Dept Pathol, Coll Med, Seoul, South Korea
[10] Yonsei Univ, Dept Pathol, Coll Med, 50-1 Yonsei,Seodaemungu, Seoul 03722, South Korea
基金
新加坡国家研究基金会;
关键词
Cyclin-dependent kinase inhibitor; Glioma; Magnetic resonance imaging; Radiogenomics; GRADE; GLIOBLASTOMA; SURVIVAL; DIFFUSE; IDH; GENE; PSEUDOPROGRESSION; DIFFERENTIATION; CLASSIFICATION; ANGIOGENESIS;
D O I
10.3348/kjr.2022.0732
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objective: Cyclin-dependent kinase inhibitor (CDKN)2A/B homozygous deletion is a key molecular marker of isocitrate dehydrogenase (IDH)-mutant astrocytomas in the 2021 World Health Organization. We aimed to investigate whether qualitative and quantitative MRI parameters can predict CDKN2A/B homozygous deletion status in IDH-mutant astrocytomas.Materials and Methods: Preoperative MRI data of 88 patients (mean age +/- standard deviation, 42.0 +/- 11.9 years; 40 females and 48 males) with IDH-mutant astrocytomas (76 without and 12 with CDKN2A/B homozygous deletion) from two institutions were included. A qualitative imaging assessment was performed. Mean apparent diffusion coefficient (ADC), 5th percentile of ADC, mean normalized cerebral blood volume (nCBV), and 95th percentile of nCBV were assessed via automatic tumor segmentation. Logistic regression was performed to determine the factors associated with CDKN2A/B homozygous deletion in all 88 patients and a subgroup of 47 patients with histological grades 3 and 4. The discrimination performance of the logistic regression models was evaluated using the area under the receiver operating characteristic curve (AUC). Results: In multivariable analysis of all patients, infiltrative pattern (odds ratio [OR] = 4.25, p = 0.034), maximal diameter (OR = 1.07, p = 0.013), and 95th percentile of nCBV (OR = 1.34, p = 0.049) were independent predictors of CDKN2A/B homozygous deletion. The AUC, accuracy, sensitivity, and specificity of the corresponding model were 0.83 (95% confidence interval [CI], 0.72-0.91), 90.4%, 83.3%, and 75.0%, respectively. On multivariable analysis of the subgroup with histological grades 3 and 4, infiltrative pattern (OR = 10.39, p = 0.012) and 95th percentile of nCBV (OR = 1.24, p = 0.047) were independent predictors of CDKN2A/B homozygous deletion, with an AUC accuracy, sensitivity, and specificity of the corresponding model of 0.76 (95% CI, 0.60-0.88), 87.8%, 80.0%, and 58.1%, respectively.Conclusion: The presence of an infiltrative pattern, larger maximal diameter, and higher 95th percentile of the nCBV may be useful MRI biomarkers for CDKN2A/B homozygous deletion in IDH-mutant astrocytomas.
引用
收藏
页码:133 / 144
页数:12
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