The Effect of Vitamin C on Blood Lymphocytes of American Mink (Neovison Vison): Variation with Sex and Genotype

被引:0
|
作者
Kizhina, Aleksandra [1 ,2 ]
Ilyukha, Viktor [1 ]
Rossinskaya, Raisa [2 ]
机构
[1] Russian Acad Sci, Inst Biol, Karelian Res Ctr, Petrozavodsk, Russia
[2] Petrozavodsk State Univ, Med Inst, Petrozavodsk, Russia
关键词
lymphocytes; vitamin C; Chediak-Higashi syndrome; Neovison vison; morphometry; CHEDIAK-HIGASHI-SYNDROME; ASCORBIC-ACID SUPPLEMENTATION; ANTIBODY-RESPONSE; IMMUNE-RESPONSE; CELLS; PARAMETERS; ESTERASE; DISEASE;
D O I
10.1590/1678-4324-2023210340
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Vitamin C (VC) is involved in many biological processes including immune response. This experiment was conducted to investigate the effects of supplemental VC on the development of mink lymphocytes in wild type (Standard genotype mink) and animal model of Chediak-Higashy (CH) syndrome (Sapphire genotype mink). Chediak-Higashy syndrome is genetically determined disease of human and animals affecting morphology and functions different cells including leukocytes. Using morphometry and cytochemistry methods, we reveal that VC supplementation (100 mg/animal/day) induces lymphocyte activation in wild type mink and CH-like mink. However, the effect of VC supplementation is sex-related and depends on the genotype of mink. In general, we obtained data that VC supplementation neutralizes genotype-related size differences among lymphocytes.
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页数:8
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