The potential influence of melatonin on mitochondrial quality control: a review

被引：10
作者：
Lei, Xudan [1 ]
Xu, Zhenni [1 ]
Huang, Lingxiao [1 ]
Huang, Yujun [2 ]
Tu, Siyu [2 ]
Xu, Lu [1 ]
Liu, Dengqun [1 ,2 ]
机构：
[1] Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Sichuan Clin Res Ctr Canc, Sichuan Canc Ctr.Affiliated Canc Hosp,Dept Expt Re, Chengdu, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Coll Basic Med, Chengdu, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2024年 / 14卷
基金：
中国国家自然科学基金;
关键词：
autophagy; melatonin; mitochondrial dynamics; mitochondria-related diseases; oxidative phosphorylation; ISCHEMIA-REPERFUSION INJURY; RESPIRATORY-CHAIN ACTIVITY; OXIDATIVE STRESS; ER STRESS; INDUCED NEUROTOXICITY; INDUCED APOPTOSIS; PERIPHERAL-BLOOD; REACTIVE OXYGEN; GENE-EXPRESSION; PINEAL-GLAND;
D O I：
10.3389/fphar.2023.1332567
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Mitochondria are critical for cellular energetic metabolism, intracellular signaling orchestration and programmed death regulation. Therefore, mitochondrial dysfunction is associated with various pathogeneses. The maintenance of mitochondrial homeostasis and functional recovery after injury are coordinated by mitochondrial biogenesis, dynamics and autophagy, which are collectively referred to as mitochondrial quality control. There is increasing evidence that mitochondria are important targets for melatonin to exert protective effects under pathological conditions. Melatonin, an evolutionarily conserved tryptophan metabolite, can be synthesized, transported and metabolized in mitochondria. In this review, we summarize the important role of melatonin in the damaged mitochondria elimination and mitochondrial energy supply recovery by regulating mitochondrial quality control, which may provide new strategies for clinical treatment of mitochondria-related diseases.
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收藏
页数：12
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