Assessment of lung deformation in patients with idiopathic pulmonary fibrosis with elastic registration technique on pulmonary three-dimensional ultrashort echo time MRI

被引：1

作者：

Yang, Xiaoyan ^{[1
,2
]}

Yu, Pengxin ^{[3
]}

Sun, Haishuang ^{[2
]}

Deng, Mei ^{[4
]}

Liu, Anqi ^{[4
]}

Li, Chen ^{[2
]}

Meng, Wenyan ^{[2
]}

Xu, Wenxiu ^{[2
]}

Xie, Bingbing ^{[2
]}

Geng, Jing ^{[2
]}

Ren, Yanhong ^{[2
]}

Zhang, Rongguo ^{[3
]}

Liu, Min ^{[4
]}

Dai, Huaping ^{[1
,2
]}

机构：

[1] Ningxia Med Univ, Dept Pulm & Crit Care Med, Gen Hosp, Yinchuan 750004, Ningxia, Peoples R China

[2] Chinese Acad Med Sci, Natl Ctr Resp Med,Natl Clin Res Ctr Resp Dis, China Japan Friendship Hosp,Inst Resp Med, Dept Pulm & Crit Care Med,Ctr Resp Med, 2 Yinghua Dong St, Beijing 100029, Peoples R China

[3] Infervis Med Technol Co Ltd, Inst Adv Res, Beijing 100025, Peoples R China

[4] China Japan Friendship Hosp, Dept Radiol, 2 Yinghua East St, Beijing 100029, Peoples R China

来源：

INSIGHTS INTO IMAGING | 2024年 / 15卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Elastic registration; Idiopathic pulmonary fibrosis; Magnetic resonance imaging; Ultrashort echo time; COMPUTED-TOMOGRAPHY; IMAGE REGISTRATION; AGREEMENT; HEALTHY;

D O I：

10.1186/s13244-023-01555-x

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Objective: To assess lung deformation in patients with idiopathic pulmonary fibrosis (IPF) using with elastic registration algorithm applied to three-dimensional ultrashort echo time (3D-UTE) MRI and analyze relationship of lung deformation with the severity of IPF. Methods: Seventy-six patients with IPF (mean age: 62 +/- 6 years) and 62 age- and gender-matched healthy controls (mean age: 58 +/- 4 years) were prospectively enrolled. End-inspiration and end-expiration images acquired with a single breath-hold 3D-UTE sequence were registered using elastic registration algorithm. Jacobian determinants were calculated from deformation fields and represented on color maps. Jac-mean (absolute value of the log means of Jacobian determinants) and the Dice similarity coefficient (Dice) were compared between different groups. Results: Compared with healthy controls, the Jac-mean of IPF patients significantly decreased (0.21 +/- 0.08 vs. 0.27 +/- 0. 07, p < 0.001). Furthermore, the Jac-mean and Dice correlated with the metrics of pulmonary function tests and the composite physiological index. The lung deformation in IPF patients with dyspnea Medical Research Council (MRC) >= 3 (Jac-mean: 0.16 +/- 0.03; Dice: 0.06 +/- 0.02) was significantly lower than MRC1 (Jac-mean: 0. 25 +/- 0.03, p < 0.001; Dice: 0.10 +/- 0.01, p < 0.001) and MRC 2 (Jac-mean: 0.22 +/- 0.11, p = 0.001; Dice: 0.08 +/- 0.03, p = 0.006). Meanwhile, Jac-mean and Dice correlated with health-related quality of life, 6 min-walk distance, and the extent of pulmonary fibrosis. Jac-mean correlated with pulmonary vascular-related indexes on high-resolution CT. Conclusion: The decreased lung deformation in IPF patients correlated with the clinical severity of IPF patients. Elastic registration of inspiratory-to-expiratory 3D UTE MRI may be a new morphological and functional marker for non-radiation and noninvasive evaluation of IPF.

引用

页数：13

共 32 条

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