Roles of the cerebellum and basal ganglia in temporal integration: Insights from a synchronized tapping task

被引：1

作者：

Tokushige, Shin-ichi ^{[1
,2
]}

Matsuda, Shunichi ^{[1
]}

Tada, Masayoshi ^{[3
]}

Yabe, Ichiro ^{[4
,5
]}

Takeda, Atsushi ^{[6
]}

Tanaka, Hiroyasu ^{[6
,8
]}

Hatakenaka, Megumi ^{[7
]}

Enomoto, Hiroyuki ^{[6
]}

Kobayashi, Shunsuke ^{[9
]}

Shimizu, Kazutaka ^{[10
]}

Shimizu, Takahiro ^{[11
]}

Kotsuki, Naoki ^{[2
]}

Inomata-Terada, Satomi ^{[12
]}

Furubayashi, Toshiaki ^{[13
]}

Ichikawa, Yaeko ^{[2
]}

Hanajima, Ritsuko ^{[10
]}

Tsuji, Shoji ^{[14
,15
]}

Ugawa, Yoshikazu ^{[16
]}

Terao, Yasuo ^{[1
,12
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Neurol, 7-3-1,Hongo,Bunkyo Ku, Tokyo 1138655, Japan

[2] Kyorin Univ, Fac Med, Dept Neurol, 6-20-2 Shinkawa, Mitaka, Tokyo 1818611, Japan

[3] Niigata Univ, Brain Res Inst, Dept Neurol, 1-757 Asahimachidori,Chuo Ku, Niigata 9518585, Japan

[4] Hokkaido Univ, Fac Med, Dept Neurol, Kita 15,Nishi 7,Kita Ku, Sapporo 0608638, Japan

[5] Hokkaido Univ, Grad Sch Med, Kita 15,Nishi 7,Kita Ku, Sapporo 0608638, Japan

[6] Sendai Nishitaga Hosp, Dept Neurol, 2-11-11,Kagitori Honcho,Taihaku Ku, Sendai 9828555, Japan

[7] Morinomiya Hosp, Dept Neurol, 2-1-88 Morinomiya,Joto Ku, Osaka 5360025, Japan

[8] Fukushima Med Univ, Fac Med, Dept Neurol, 1 Hikarigaoka, Fukushima 9601295, Japan

[9] Teikyo Univ, Sch Med, Dept Neurol, 2-11-1 Kaga,Itabashi Ku, Tokyo 1738606, Japan

[10] Tottori Univ, Fac Med, Dept Brain & Neurosci, Div Neurol, 36-1 Nishicho, Yonago, Tottori 6838504, Japan

[11] Kitasato Univ, Sch Med, Dept Neurol, 1-15-1,Kitazato, Sagamihara, Kanagawa 2520375, Japan

[12] Kyorin Univ, Sch Med, Dept Med Physiol, 6-20-2 Shinkawa, Mitaka, Tokyo 1818611, Japan

[13] Tohoku Bunka Gakuen Univ, Grad Sch Hlth & Environm Sci, 6-45-1 Kunimi, Sendai, Miyagi 9818551, Japan

[14] Univ Tokyo, Dept Mol Neurol, 4-3,Kozunomori, Chiba 2868686, Japan

[15] Int Univ Hlth & Welf, 4-3, Kozunomori, Chiba 2868686, Japan

[16] Fukushima Med Univ, Dept Human Neurophysiol, 1 Hikarigaoka, Fukushima 9601295, Japan

来源：

CLINICAL NEUROPHYSIOLOGY | 2024年 / 158卷

关键词：

Cerebellum; Basal ganglia; Temporal processing; Spinocerebellar degeneration; Synchronized tapping task; SENSORIMOTOR SYNCHRONIZATION; STIMULUS SEQUENCE; NEURAL SYSTEMS; TIME INTERVALS; MOTOR ACTS; ATAXIA; PERCEPTION; CORTEX; MODEL; METHAMPHETAMINE;

D O I：

10.1016/j.clinph.2023.11.018

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: The aim of this study was to clarify the roles of the cerebellum and basal ganglia for temporal integration.Methods: We studied 39 patients with spinocerebellar degeneration (SCD), comprising spinocerebellar atrophy 6 (SCA6), SCA31, Machado-Joseph disease (MJD, also called SCA3), and multiple system atrophy (MSA). Thirteen normal subjects participated as controls. Participants were instructed to tap on a button in synchrony with isochronous tones. We analyzed the inter-tap interval (ITI), synchronizing tapping error (STE), negative asynchrony, and proportion of delayed tapping as indicators of tapping performance.Results: The ITI coefficient of variation was increased only in MSA patients. The standard variation of STE was larger in SCD patients than in normal subjects, especially for MSA. Negative asynchrony, which is a tendency to tap the button before the tones, was prominent in SCA6 and MSA patients, with possible basal ganglia involvement. SCA31 patients exhibited normal to supranormal performance in terms of the variability of STE, which was surprising. Conclusions: Cerebellar patients generally showed greater STE variability, except for SCA31. The pace of tapping was affected in patients with possible basal ganglia pathology.Significance: Our results suggest that interaction between the cerebellum and the basal ganglia is essential for temporal processing. The cerebellum and basal ganglia and their interaction regulate synchronized tapping, resulting in distinct tapping pattern abnormalities among different SCD subtypes.CO 2023 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

引用

页码：1 / 15

页数：15

共 97 条

[1] Anatomical and physiological foundations of cerebellar information processing [J].

Apps, R ;

Garwicz, M .

NATURE REVIEWS NEUROSCIENCE, 2005, 6 (04) :297-311

[2] SYNCHRONIZING ACTIONS WITH EVENTS - THE ROLE OF SENSORY INFORMATION [J].

ASCHERSLEBEN, G ;

PRINZ, W .

PERCEPTION & PSYCHOPHYSICS, 1995, 57 (03) :305-317

[3] The Cerebellum Predicts the Temporal Consequences of Observed Motor Acts [J].

Avanzino, Laura ;

Bove, Marco ;

Pelosin, Elisa ;

Ogliastro, Carla ;

Lagravinese, Giovanna ;

Martino, Davide .

PLOS ONE, 2015, 10 (02)

[4] Impaired predictive motor timing in patients with cerebellar disorders [J].

Bares, Martin ;

Lungu, Ovidiu ;

Liu, Tao ;

Waechter, Tobias ;

Gomez, Christopher M. ;

Ashe, James .

EXPERIMENTAL BRAIN RESEARCH, 2007, 180 (02) :355-365

[5] Consensus paper: Decoding the Contributions of the Cerebellum as a Time Machine. From Neurons to Clinical Applications [J].

Bares, Martin ;

Apps, Richard ;

Avanzino, Laura ;

Breska, Assaf ;

D'Angelo, Egidio ;

Filip, Pavel ;

Gerwig, Marcus ;

Ivry, Richard B. ;

Lawrenson, Charlotte L. ;

Louis, Elan D. ;

Lusk, Nicholas A. ;

Manto, Mario ;

Meck, Warren H. ;

Mitoma, Hiroshi ;

Petter, Elijah A. .

CEREBELLUM, 2019, 18 (02) :266-286

[6] The Neural Substrate of Predictive Motor Timing in Spinocerebellar Ataxia [J].

Bares, Martin ;

Lungu, Ovidiu V. ;

Liu, Tao ;

Waechter, Tobias ;

Gomez, Christopher M. ;

Ashe, James .

CEREBELLUM, 2011, 10 (02) :233-244

[7] Predictive Motor Timing Performance Dissociates Between Early Diseases of the Cerebellum and Parkinson's Disease [J].

Bares, Martin ;

Lungu, Ovidiu V. ;

Husarova, Ivica ;

Gescheidt, Tomas .

CEREBELLUM, 2010, 9 (01) :124-135

[8] The basal ganglia and the cerebellum: nodes in an integrated network [J].

Bostan, Andreea C. ;

Strick, Peter L. .

NATURE REVIEWS NEUROSCIENCE, 2018, 19 (06) :338-350

[9] The basal ganglia communicate with the cerebellum [J].

Bostan, Andreea C. ;

Dum, Richard P. ;

Strick, Peter L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (18) :8452-8456

[10] The human cerebellum is essential for modulating perceptual sensitivity based on temporal expectations [J].

Breska, Assaf ;

Ivry, Richard B. .

ELIFE, 2021, 10

← 1 2 3 4 5 6 7 8 9 10 →