Childhood outcomes after maternal antenatal sildenafil treatment for severe early-onset fetal growth restriction: a randomized trial (STRIDER NZAus)

被引：2
|
作者：
McKinlay, Christopher J. D. [1 ,2 ]
Anderson, Chad [3 ]
Cheong, Jeanie L. Y. [4 ,5 ,6 ]
Gordon, Adrienne [7 ]
Harris, Sarah L. [8 ,9 ]
Hurrion, Elizabeth M. [10 ,11 ]
Ireland, Susan [12 ]
Koorts, Pieter [13 ]
Lui, Kei [14 ]
Mackay, Laura [15 ]
Bals, Mariska Oakes-Ter [15 ]
Opie, Gillian [16 ]
Sharp, Mary [17 ,18 ]
Groom, Katie M. [15 ]
机构：
[1] Univ Auckland, Paediat Child & Youth Hlth, Auckland, New Zealand
[2] Cty Manukau Hlth, Kidz First Neonatal Care, Auckland, New Zealand
[3] Womens & Childrens Hosp, Adelaide, SA, Australia
[4] Royal Womens Hosp, Melbourne, Vic, Australia
[5] Murdoch Childrens Res Inst, Clin Sci, Melbourne, Vic, Australia
[6] Univ Melbourne, Obstet & Gynaecol, Melbourne, Vic, Australia
[7] Royal Prince Alfred Hosp, Sydney, NSW, Australia
[8] Univ Otago, Christchurch, New Zealand
[9] Te Whatu Ora Waitaha, Christchurch, New Zealand
[10] Mater Mothers Hosp, Brisbane, Qld, Australia
[11] Univ Queensland, Mater Res Inst, Brisbane, Qld, Australia
[12] Townsville Univ Hosp, Townsville, Qld, Australia
[13] Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia
[14] Univ New South Wales, Sch Clin Med, Sydney, Australia
[15] Univ Auckland, Liggins Inst, Auckland, New Zealand
[16] Mercy Hosp Women, Melbourne, Vic, Australia
[17] King Edward Mem Hosp, Perth, WA, Australia
[18] Univ Western Australia, Perth, WA, Australia
来源：
JOURNAL OF PERINATOLOGY | 2024年 / 44卷 / 03期
关键词：
FOR-GESTATIONAL-AGE; CARDIOVASCULAR RISK; CITRATE TREATMENT; BLOOD-PRESSURE; BIRTH-WEIGHT; BRAIN-INJURY; INFANTS; BORN; PREDICTORS; RECOVERY;
D O I：
10.1038/s41372-023-01838-7
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
In this follow-up at 2.5 years of children from the STRIDER NZAus Trial (N = 112), in which women with singleton pregnancies affected by severe early fetal growth restriction were randomized to sildenafil citrate 75 mg daily or placebo until 32 weeks, there was no difference between groups in survival without neurosensory impairment, defined as any of cerebral palsy, deafness, blindness, cognitive delay (Bayley III cognition or language score >1 SD below mean) or motor delay: 30/56[54%] vs. 34/56[61%]; aOR = 0.74, 95%CI: 0.31, 1.77. However, children exposed to sildenafil appeared to be more likely to have cognitive delay (13/45[29%] vs. 4/40[10%]; aOR = 3.71, 95% CI: 1.01, 13.63) but less likely to have emotional-behavioural difficulties (2/43[5%] vs. 8/38[21%]; aOR = 0.19, 95%CI: 0.03, 1.00). Conclusion: maternal sildenafil treatment for severe early-onset FGR was not associated with altered survival free of neurosensory impairment at 2.5 years' corrected age.
引用
收藏
页码：396 / 403
页数：8
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