Role of Resolvins in Inflammatory and Neuropathic Pain

被引:5
作者
Park, Jaeik [1 ,2 ]
Roh, Jueun [1 ,2 ]
Pan, Jingying [1 ,2 ,3 ]
Kim, Yong Ho [1 ,2 ]
Park, Chul-Kyu [1 ,2 ]
Jo, Youn Yi [4 ]
机构
[1] Gachon Univ, Gachon Pain Ctr, Coll Med, Incheon 21999, South Korea
[2] Gachon Univ, Dept Physiol, Coll Med, Incheon 21999, South Korea
[3] Nantong Univ, Dept Histol & Embryol, Med Sch, Nantong 226007, Peoples R China
[4] Gachon Univ, Gil Med Ctr, Dept Anesthesiol & Pain Med, Incheon 21565, South Korea
基金
新加坡国家研究基金会;
关键词
resolvin; inflammatory pain; neuropathic pain; inflammation; pain management; dorsal root ganglia; spinal cord; ANTIINFLAMMATORY PROPERTIES; DOCOSAHEXAENOIC ACID; LIPID MEDIATORS; HUMAN BLOOD; FISH-OIL; D1; RESOLUTION; RECEPTOR; OMEGA-3-FATTY-ACIDS; RAT;
D O I
10.3390/ph16101366
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Chronic pain is an unpleasant experience associated with actual or potential tissue damage. Inflammatory pain alerts the body to inflammation and promotes healing; however, unresolved inflammation can lead to chronic pain. Conversely, neuropathic pain, due to somatosensory damage, can be a disease in itself. However, inflammation plays a considerable role in the progression of both types of pain. Resolvins, derived from omega-3 fatty acids, actively suppress pro-inflammatory mediators and aid in the resolution of inflammation. Resolvins alleviate various inflammatory and neuropathic pain models by reducing hypersensitivity and regulating inflammatory cytokines and glial activation in the spinal cord and dorsal root ganglia. Thus, resolvins are a promising alternative for pain management with the potential to reduce the side effects associated with conventional medications. Continued research is crucial to unlock the therapeutic potential of resolvins and integrate them into effective clinical pain management strategies. This review aimed to evaluate the literature surrounding the resolvins in inflammatory and neuropathic pain.
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页数:16
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