Recent advances in the photophysical detection and delivery of singlet oxygen

被引:16
作者
Joseph, Suman [1 ]
Kumar, S. K. Ashok [1 ]
机构
[1] Vellore Inst Technol, Sch Adv Sci, Dept Chem, Vellore 632014, Tamil Nadu, India
关键词
Singlet oxygen; Reactive oxygen species; Photodynamic therapy; Probe; Molecular carriers; WATER-SOLUBLE TRAP; PHOTODYNAMIC THERAPY; MOLECULAR-OXYGEN; CATALYZED CHEMILUMINESCENCE; LUMINESCENCE DETECTION; FLUORESCENCE PROBE; SENSOR GREEN; ENDOPEROXIDE; RELEASE; GENERATION;
D O I
10.1016/j.ccr.2023.215408
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Singlet oxygen (1O2) is an important reactive oxygen species (ROS) in chemistry, medicine, and human physiology. It has significant real-world applications in photodynamic therapy (PDT) and organic transformations. However, its adoption in biological systems has been minimal due to a lack of efficient probes for detecting, quantifying, imaging, and delivering 1O2 in physiological conditions. This review will discuss current developments of probes and molecular carriers (MC) of 1O2. The developments in their molecular design and mechanism documented in the literature have been discussed. Most probes and carriers are molecular dyads bearing a 1O2-specific binding unit (BU) and a signaling unit (SU). The BUs of probes and carriers comprise motifs like acene, alkene, furan, pyrrole, imidazole, and 2-pyridone. Based on the signaling mode, these probes could be divided into four categories: absorption-based, colorimetric, photoluminescent, and chemiluminescent. Furthermore, we elaborated on the factors determining their efficiency and identified the unexplored areas with massive potential. This review could be a useful reference for the future development of 1O2 tools.
引用
收藏
页数:30
相关论文
共 175 条
[1]   Water-Soluble Fluorescent Polymers that Respond to Singlet Oxygen [J].
Altinok, Esra ;
Frausto, Fanny ;
Thomas, Samuel W., III .
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2016, 54 (16) :2526-2535
[2]   Two-Dimensional, Acene-Containing Conjugated Polymers That Show Ratiometric Fluorescent Response to Singlet Oxygen [J].
Altinok, Esra ;
Smith, Zachary C. ;
Thomas, Samuel W., III .
MACROMOLECULES, 2015, 48 (19) :6825-6831
[3]   Furan-Containing Singlet Oxygen-Responsive Conjugated Polymers [J].
Altinok, Esra ;
Friedle, Simone ;
Thomas, Samuel W., III .
MACROMOLECULES, 2013, 46 (03) :756-762
[4]   Proof-of-principle for two-stage photodynamic therapy: hypoxia triggered release of singlet oxygen [J].
Ayan, Seylan ;
Gunaydin, Gurcan ;
Yesilgul-Mehmetcik, Nisa ;
Gedik, M. Emre ;
Seven, Ozlem ;
Akkaya, Engin U. .
CHEMICAL COMMUNICATIONS, 2020, 56 (94) :14793-14796
[5]   Steric and Electronic Substituent Effects Influencing Regioselectivity of Tetracene Endoperoxidation [J].
Baral, Rom Nath ;
Thomas, Samuel W., III .
JOURNAL OF ORGANIC CHEMISTRY, 2015, 80 (21) :11086-11091
[6]  
Barik A., 2006, Singlet oxygen: Photosensitized generation, detection and reaction with organic molecules
[7]   Storable, thermally activated, near-infrared chemiluminescent dyes and dye-stained microparticles for optical imaging [J].
Baumes, Jeffrey M. ;
Gassensmith, Jeremiah J. ;
Giblin, Jay ;
Lee, Jung-Jae ;
White, Alexander G. ;
Culligan, William J. ;
Leevy, W. Matthew ;
Kuno, Masaru ;
Smith, Bradley D. .
NATURE CHEMISTRY, 2010, 2 (12) :1025-1030
[8]   Mitochondria-Assisted Photooxidation to Track Singlet Oxygen at Homeostatic Membrane Microviscosity [J].
Bernal-Escalante, Jasmine ;
Molina-Villa, Tonatiuh ;
Lopez-Casillas, Fernando ;
Jimenez-Sanchez, Arturo .
ACS SENSORS, 2022, 7 (08) :2303-2311
[9]   Dioxygen: What Makes This Triplet Diradical Kinetically Persistent? [J].
Borden, Weston Thatcher ;
Hoffmann, Roald ;
Stuyver, Thijs ;
Chen, Bo .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2017, 139 (26) :9010-9018
[10]   Acenes beyond organic electronics: sensing of singlet oxygen and stimuli-responsive materials [J].
Brega, Valentina ;
Yan, Yu ;
Thomas, Samuel W., III .
ORGANIC & BIOMOLECULAR CHEMISTRY, 2020, 18 (45) :9191-9209