A neural circuit for male sexual behavior and reward

被引：31

作者：

Bayless, Daniel W. ^{[1
,2
]}

Davis, Chung-ha O. ^{[3
]}

Yang, Renzhi ^{[1
,2
]}

Wei, Yichao ^{[1
,2
]}

Carvalho, Vinicius Miessler de Andrade ^{[1
,2
]}

Knoedler, Joseph R. ^{[1
,2
]}

Yang, Taehong ^{[1
,2
]}

Livingston, Oscar ^{[1
,2
]}

Lomvardas, Akira ^{[1
,2
]}

Martins, Gabriela J. ^{[11
]}

Vicente, Ana Mafalda ^{[11
,12
]}

Ding, Jun B. ^{[4
,5
,6
]}

Luo, Liqun ^{[7
,8
,9
]}

Shash, Nirao M. ^{[1
,2
,9
,10
]}

机构：

[1] Stanford Univ, Dept Psychiat, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Behav Sci, Stanford, CA 94305 USA

[3] Stanford Univ, Stanford Neurosci Grad Program, Stanford, CA 94305 USA

[4] Stanford Univ, Dept Neurosurg, Stanford, CA 94305 USA

[5] Stanford Univ, Dept Neurol, Stanford, CA 94305 USA

[6] Stanford Univ, Dept Neurol Sci, Stanford, CA 94305 USA

[7] Stanford Univ, Dept Biol, Stanford, CA 94305 USA

[8] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA

[9] Stanford Univ, Dept Neurobiol, Stanford, CA 94305 USA

[10] Stanford Univ, Dept Obstet & Gynecol, Stanford, CA 94305 USA

[11] Allen Inst Neural Dynam, Seattle, WA 98109 USA

[12] Columbia Univ, Zuckerman Mind Brain Behav Inst, New York, NY 10027 USA

来源：

CELL | 2023年 / 186卷 / 18期

关键词：

sexual behavior; pheromones; recognizes mates; triggers; MEDIAL PREOPTIC AREA; SOCIAL-BEHAVIOR; SUBSTANCE-P; COPULATORY-BEHAVIOR; BED NUCLEUS; ELECTRICAL-STIMULATION; MALE-RATS; ULTRASONIC VOCALIZATIONS; STRIA TERMINALIS; SELF-STIMULATION;

D O I：

10.1016/j.cell.2023.07.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Male sexual behavior is innate and rewarding. Despite its centrality to reproduction, a molecularly specified neural circuit governing innate male sexual behavior and reward remains to be characterized. We have discovered a developmentally wired neural circuit necessary and sufficient for male mating. This circuit connects chemosensory input to BNSTpr(Tac1) neurons, which innervate POA(Tacr1) neurons that project to centers regulating motor output and reward. Epistasis studies demonstrate that BNSTpr(Tac1) neurons are upstream of POA(Tacr1) neurons, and BNSTpr(Tac1)-released substance P following mate recognition potentiates activation of POA(Tacr1) neurons through Tacr1 to initiate mating. Experimental activation of POA(Tacr1) neurons triggers mating, even in sexually satiated males, and it is rewarding, eliciting dopamine release and self-stimulation of these cells. Together, we have uncovered a neural circuit that governs the key aspects of innate male sexual behavior: motor displays, drive, and reward.

引用

页码：3862 / +

页数：49

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