Higher versus lower nut consumption and changes in cognitive performance over two years in a population at risk of cognitive decline: a cohort study

被引：5

作者：

Ni, Jiaqi ^{[1
,2
,3
]}

Nishi, Stephanie K. ^{[1
,2
,3
,4
,5
]}

Babio, Nancy ^{[1
,2
,3
]}

Ros, Emilio ^{[3
,6
]}

Basterra-Gortari, F. Javier ^{[7
,8
]}

Corella, Dolores ^{[3
,9
]}

Castaner, O. ^{[10
,11
]}

Martinez, J. Alfredo ^{[3
,12
,13
]}

Alonso-Gomez, Angel M. ^{[3
,14
,15
,16
]}

Warnberg, Julia ^{[3
,17
]}

Vioque, Jesus ^{[10
,18
]}

Romaguera, Dora ^{[3
,19
]}

Lopez-Miranda, Jose ^{[3
,20
]}

Estruch, Ramon ^{[3
,21
,22
]}

Tinahones, Francisco J. ^{[3
,23
]}

Santos-Lozano, Jose Manuel ^{[3
,24
]}

Serra-Majem, Lluis ^{[3
,25
,26
]}

Cano-Ibanez, Naomi ^{[10
,28
,29
]}

Tur, Josep A. ^{[3
,27
]}

Fernandez-Garcia, Jose Manuel ^{[30
,31
]}

Pinto, Xavier ^{[3
,32
]}

Delgado-Rodriguez, Miguel ^{[13
,33
]}

Matia-Martin, Pilar ^{[34
]}

Vidal, Josep ^{[35
,36
]}

Vazquez, Clotilde ^{[3
,37
]}

Daimiel, Lidia ^{[3
,38
,39
]}

Fernandez-Aranda, Fernando ^{[3
,40
,41
]}

Ruiz-Canela, Miguel ^{[3
,7
]}

Sola, Cristina Mestres ^{[42
]}

Portoles, Olga ^{[3
,9
]}

Sala-Vila, Aleix ^{[3
,11
]}

Garcia-Rios, Antonio ^{[3
,20
]}

Compan-Gabucio, Laura Maria ^{[10
,18
]}

Gomez-Gracia, Enrique ^{[43
,44
]}

Zulet, M. Angeles ^{[3
,12
]}

Chaplin, Alice ^{[3
,19
]}

Casas, Rosa ^{[3
,21
,22
]}

Martinez-Diz, Silvia ^{[45
]}

Tojal-Sierra, Lucas ^{[3
,14
,15
,16
,20
]}

Gomez-Perez, Ana Maria ^{[3
,23
]}

Toledo, Estefania ^{[3
,7
]}

Rios, Santiago ^{[1
,2
,3
]}

Ortega-Azorin, Carolina ^{[3
,9
]}

de la Torre, Rafael ^{[3
,46
,47
]}

Pena-Orihuela, Patricia J. ^{[3
,20
]}

Garcia-de la Hera, Manuela ^{[10
,18
]}

Sayon-Orea, Carmen ^{[3
,7
]}

Malcampo, Mireia ^{[11
]}

PREDIMED Plus Investigators ^{[1
,2
,3
]}

机构：

[1] Univ Rovira i Virgili, Dept Bioquim & Biotecnol Alimentacio Nutr Desenvol, Unitat Nutr Humana, Reus, Spain

[2] Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain

[3] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBER, Madrid, Spain

[4] Toronto 3D Diet Digest Tract & Dis Knowledge Synth, Toronto, ON, Canada

[5] Unity Hlth Toronto, St Michaels Hosp, Clin Nutr & Risk Factor Modificat Ctr, Toronto, ON, Canada

[6] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr, Lipid Clin, Barcelona, Spain

[7] Univ Navarra, IdiSNA, Dept Prevent Med & Publ Hlth, Pamplona, Spain

[8] Univ Publ Navarra, Hosp Univ Navarra, IdiSNA, Dept Endocrinol & Nutr, Pamplona, Spain

[9] Univ Valencia, Dept Prevent Med, Valencia, Spain

[10] Inst Salud Carlos III, Ctr Invest Biomed Red Epidemiol & Salud Publ CIBER, Madrid, Spain

[11] Inst Hosp Mar Invest Med Municipal Invest Med IMIM, Unit Cardiovasc Risk & Nutr, Barcelona, Spain

[12] Univ Navarra, IdiSNA, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona, Spain

[13] IMDEA Food CEI UAM CSIC, Precis Nutr & Cardiometab Hlth Program, Madrid, Spain

[14] Bioaraba Hlth Res Inst, Cardiovasc Resp & Metab Area, Vitoria, Spain

[15] Araba Univ Hosp, Osakidetza Basque Hlth Serv, Vitoria, Spain

[16] Univ Basque Country UPV EHU, Vitoria, Spain

[17] Univ Malaga, Inst Invest Biomed Malaga IBIMA, Sch Hlth Sci, EpiPHAAN Res Grp, Malaga, Spain

[18] Univ Miguel Hernandez ISABIAL UMH, Inst Invest Sanitaria & Biomed Alicante, Alicante, Spain

[19] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca, Spain

[20] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Dept Internal Med, Cordoba, Spain

[21] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Internal Med, Barcelona, Spain

[22] Univ Barcelona, Inst Recerca Nutr & Seguretata Alimentaria INSA UB, Barcelona, Spain

[23] Univ Malaga, Virgen Victoria Hosp, Dept Endocrinol, Inst Invest Biomed Malaga IBIMA, Malaga, Spain

[24] Dist Sanitario Atenc Primaria Sevilla, Dept Family Med, Res Unit, Seville, Spain

[25] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Las Palmas Gran Canaria, Spain

[26] Ctr Hosp Univ Insular Materno Infantil CHUIMI, Canarian Hlth Serv, Las Palmas Gran Canaria, Spain

[27] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain

[28] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain

[29] Inst Invest Biosanit Granada ibs GRANADA, Granada, Spain

[30] Soc Espanola Med Atenc Primaria SEMERGEN, Ctr Salud Valga, Grp Trabajo Nutr, Med Familiar & Comunitaria, Pontevedra, Spain

[31] Univ Santiago De Compostela, Dept Psychiat Radiol Publ Hlth Nursing & Med, Santiago De Compostela, Spain

[32] Hosp Univ Bellvitge IDIBELL, Lipids & Vasc Risk Unit, Internal Med, Barcelona, Spain

[33] Univ Jaen, Fac Med, Div Prevent Med, Jaen, Spain

[34] Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Madrid, Spain

[35] Inst Salud Carlos III, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain

[36] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol, Barcelona, Spain

[37] Univ Autonoma, Hosp Fdn Jimenez Diaz, Inst Invest Biomed IISFJD, Dept Endocrinol & Nutr, Madrid, Spain

[38] CEI UAM CSIC, IMDEA Food, Precis Nutr & Obes Program, Nutr Control Epigenome Grp, Madrid, Spain

[39] Univ San Pablo CEU, CEU Univ, Fac Farm, Dept Ciencias Farmaceut & Salud,Urbanizac Montepri, Boadilla Del Monte 28660, Spain

[40] Univ Hosp Bellvitge, Clin Psychol Unit, Inst Invest Biomed Bellvitge IDIBELL, Barcelona, Spain

[41] Univ Barcelona, Sch Med & Hlth Sci, Dept Clin Sci, Barcelona, Spain

[42] Med Familia CAP Vandellos Hospitalet, Hospitalet De Linfant, Spain

[43] Univ Malaga, Sch Med, Prevent Med & Publ Hlth Dept, Malaga 29010, Spain

[44] Biomed Res Inst Malaga IBIMA Plataforma BIONAND, Malaga 29010, Spain

[45] Hosp Univ Clin San Cecilio, Serv Prevent Med & Publ Hlth, Granada 18016, Spain

[46] Hosp Mar Med Res Inst, Integrat Pharmacol & Syst Neurosci Res Grp, Barcelona, Spain

[47] Univ Pompeu Fabra, Dept Med & Life Sci MELIS, Barcelona, Spain

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2023年 / 118卷 / 02期

基金：

欧洲研究理事会; 欧盟地平线“2020”; 加拿大健康研究院;

关键词：

aging; nuts; unsaturated fatty acids; cognitive decline; cognition; older people; MIDDLE-AGED MEN; MEDITERRANEAN DIET; INTERVENTION; METAANALYSIS; PEANUT; WOMEN;

D O I：

10.1016/j.ajcnut.2023.05.032

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Tree nuts and peanuts (henceforth, nuts) are nutrient-dense foods rich in neuroprotective components; thus, their consumption could benefit cognitive health. However, evidence to date is limited and inconsistent regarding the potential benefits of nuts for cognitive function.Objective: To prospectively evaluate the association between nut consumption and 2-y changes in cognitive performance in older adults at cognitive decline risk.Methods: A total of 6,630 participants aged 55 to 75 y (mean age 65.0 & PLUSMN;4.9 y, 48.4% women) with overweight/obesity and metabolic syndrome completed a validated semi-quantitative food frequency questionnaire and a comprehensive battery of neuropsychological tests at baseline and a 2-y follow-up. Composite cognitive scores were used to assess global, general, attention, and executive function domains. Nut consumption was categorized as <1, >1 to <3, >3 to <7, and >7 servings/wk (1 serving=30 g). Multivariable-adjusted linear regression models were fitted to assess associations between baseline nut consumption and 2-y cognitive changes.Results: Nut consumption was positively associated with 2-y changes in general cognitive function (P-trend <0.001). Compared with participants consuming <1 serving/wk of nuts, those categorized as consuming >3 to <7 and >7 servings/wk showed more favorable changes in general cognitive performance (& beta; z-score [95% CI] = 0.06 [0.00,0.12] and 0.13 [0.06,0.20], respectively). No significant changes were observed in the multivariableadjusted models for other cognitive domains assessed.Conclusion: Frequent nut consumption was associated with a smaller decline in general cognitive performance over 2 y in older adults at risk of cognitive decline. Randomized clinical trials to verify our findings are warranted.

引用

页码：360 / 368

页数：9