Commander-in-chief: monocytes rally the troops for defense against aspergillosis

被引：5

作者：

Wang, Keyi ^{[1
,2
]}

Espinosa, Vanessa ^{[1
]}

Rivera, Amariliz ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Ctr Immun & Inflammat Rutgers Biomed & Hlth Sci, Newark, NJ 07103 USA

[2] Univ Med & Dent New Jersey, Sch Grad Studies Rutgers Biomed & Hlth Sci, Newark, NJ USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2023年 / 84卷

关键词：

INVASIVE PULMONARY ASPERGILLOSIS; ALVEOLAR MACROPHAGES; IMMUNE-RESPONSE; FUMIGATUS; NEUTROPHILS; INFECTION; RECRUITMENT;

D O I：

10.1016/j.coi.2023.102371

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The detrimental impact of fungal infections to human health has steadily increased over the past decades. In October of 2022, the World Health Organization published the first ever fungalpathogen priority list highlighting increased awareness of this problem, and the need for more research in this area. There were four distinct fungal pathogens identified as critical priority groups with Aspergillus fumigatus (Af) being the only mold. Af is a common environmental fungus responsible for over 90% of invasive aspergillosis cases worldwide. Pulmonary protection against Af is critically dependent on innate effector cells with essential roles played by neutrophils and monocytes. In this review, we will summarize our current understanding of how monocytes help orchestrate antifungal defense against Af.

引用

页数：6

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