High speed 4D in-vivo OCT imaging of the human brain: Creating high density datasets for machine learning toward identification of malign tissue in real time

被引:3
作者
Draxinger, Wolfgang [1 ]
Theisen-Kunde, Dirk [2 ]
Schuetzeck, Lion [2 ]
Detrez, Nicolas [2 ]
Strenge, Paul [2 ]
Danicke, Veit [2 ]
Kren, Jessica [3 ]
Kuppler, Patrick [3 ]
Spahr-Hess, Sonja [3 ]
Bonsanto, Matteo Mario [3 ]
Brinkmann, Ralf [1 ,2 ]
Huber, Robert [1 ,2 ]
机构
[1] Univ Lubeck, Inst Biomed Opt BMO, Lubeck, Germany
[2] Med Laserzentrum Lubeck MLL, Lubeck, Germany
[3] Univ Klinikum Schleswig Holstein UKSH, Lubeck, Germany
来源
HIGH-SPEED BIOMEDICAL IMAGING AND SPECTROSCOPY VIII | 2023年 / 12390卷
基金
欧盟地平线“2020”;
关键词
optical coherence tomography; intraoperative imaging; neuro surgery; surgical guidance; oncology; OPTICAL COHERENCE TOMOGRAPHY; DOMAIN; NEURONAVIGATION; LASER; RESECTION; ACCURACY;
D O I
10.1117/12.2648505
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
Neuro-surgery is challenged by the difficulties of determining brain tumor boundaries during excisions. Optical Coherence Tomography is investigated as an imaging modality for providing a viable contrast channel. Our MHz-OCT technology enables rapid volumetric imaging, suitable for surgical workflows. We present a surgical microscope integrated MHz-OCT imaging system, which is used for the collection of in-vivo images of human brains, with the purpose of being used in machine learning systems that shall be trained to identify and classify tumorous tissue.
引用
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页数:6
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共 32 条
[1]   Pilot feasibility study of in vivo intraoperative quantitative optical coherence tomography of human brain tissue during glioma resection [J].
Almasian, Mitra ;
Wilk, Leah S. ;
Bloemen, Paul R. ;
van Leeuwen, Ton G. ;
ter Laan, Mark ;
Aalders, Maurice C. G. .
JOURNAL OF BIOPHOTONICS, 2019, 12 (10)
[2]   Time-domain and spectral-domain optical coherence tomography in the analysis of brain tumor tissue [J].
Boehringer, H. J. ;
Boller, D. ;
Leppert, J. ;
Knopp, U. ;
Lankenau, E. ;
Reusche, E. ;
Huettmann, G. ;
Giese, A. .
LASERS IN SURGERY AND MEDICINE, 2006, 38 (06) :588-597
[3]   Imaging of human brain tumor tissue by near-infrared laser coherence tomography [J].
Boehringer, H. J. ;
Lankenau, E. ;
Stellmacher, F. ;
Reusche, E. ;
Huettmann, G. ;
Giese, A. .
ACTA NEUROCHIRURGICA, 2009, 151 (05) :507-517
[4]   Automatic scanning of large tissue areas in neurosurgery using optical coherence tomography [J].
Finke, M. ;
Kantelhardt, S. ;
Schlaefer, A. ;
Bruder, R. ;
Lankenau, E. ;
Giese, A. ;
Schweikard, A. .
INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY, 2012, 8 (03) :327-336
[5]   Brain shift in neuronavigation of brain tumors: A review [J].
Gerard, Ian J. ;
Kersten-Oertel, Marta ;
Petrecca, Kevin ;
Sirhan, Denis ;
Hall, Jeffery A. ;
Collins, D. Louis .
MEDICAL IMAGE ANALYSIS, 2017, 35 :403-420
[6]   Continuous spectral zooming for in vivo live 4D-OCT with MHz A-scan rates and long coherence [J].
Goeb, Madita ;
Pfeiffer, Tom ;
Draxinger, Wolfgang ;
Lotz, Simon ;
Kolb, Jan Philip ;
Huber, Robert .
BIOMEDICAL OPTICS EXPRESS, 2022, 13 (02) :713-727
[7]   A detailed analysis of the coherence and field properties of an FDML laser by time resolved beat signal measurements [J].
Grill, Christin ;
Bloemker, Torben ;
Schmidt, Mark ;
Kastner, Dominic ;
Pfeiffer, Tom ;
Kolb, Jan Philip ;
Draxinger, Wolfgang ;
Karpf, Sebastian ;
Jirauschek, Christian ;
Huber, Robert .
FIBER LASERS XVIII: TECHNOLOGY AND SYSTEMS, 2021, 11665
[8]   Theranostic applications of optical coherence tomography in neurosurgery? [J].
Hartmann, Karl ;
Stein, Klaus-Peter ;
Neyazi, Belal ;
Sandalcioglu, I. Erol .
NEUROSURGICAL REVIEW, 2022, 45 (01) :421-427
[9]   Optical coherence tomography of cranial dura mater: Microstructural visualization in vivo [J].
Hartmann, Karl ;
Stein, Klaus-Peter ;
Neyazi, Belal ;
Sandalcioglu, I. Erol .
CLINICAL NEUROLOGY AND NEUROSURGERY, 2021, 200
[10]   Microscope integrated optical coherence tomography of a cerebral arachnoid cyst: A new technique to increase intraoperative security [J].
Hartmann, Karl ;
Stein, Klaus-Peter ;
Neyazi, Belal ;
Sandalcioglu, I. Erol .
JOURNAL OF CLINICAL NEUROSCIENCE, 2020, 82 :29-31