The Brain and Spinal Microvasculature in Normal Aging

被引：2

作者：

Khaing, Zin Z. ^{[1
,3
]}

Chandrasekaran, Abarajithan ^{[1
]}

Katta, Anjali ^{[1
]}

Reed, May J. ^{[2
]}

机构：

[1] Univ Washington, Dept Neurol Surg, Seattle, WA 98195 USA

[2] Univ Washington, Div Gerontol & Geriatr Med, Dept Med, Seattle, WA 98195 USA

[3] Univ Washington, Dept Neurol Surg, 1959 NE Pacific St, Room RR715, POB 356470, Seattle, WA 98195 USA

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2023年 / 78卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Brain; Microvessels; Normal aging; Spinal cord; IMPAIRS ANGIOGENIC CAPACITY; LIMB BLOOD-FLOW; ARTERIAL STIFFNESS; ENDOTHELIAL-CELLS; WHITE-MATTER; PERIVASCULAR DRAINAGE; BARRIER DISRUPTION; ADVANCING AGE; GROWTH-FACTOR; NITRIC-OXIDE;

D O I：

10.1093/gerona/glad107

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Changes in the brain and spinal cord microvasculature during normal aging contribute to the "sensitive" nature of aged central nervous system tissue to ischemic insults. In this review, we will examine alterations in the central nervous system microvasculature during normal aging, which we define as aging without a dominant pathology such as neurodegenerative processes, vascular injury or disease, or trauma. We will also discuss newer technologies to improve the study of central nervous system microvascular structure and function. Microvasculature within the brain and spinal cord will be discussed separately as anatomy and physiology differ between these compartments. Lastly, we will identify critical areas for future studies as well as key unanswered questions.

引用

页码：1309 / 1319

页数：11

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