Association of loneliness, social isolation, and daily cognitive function in Mexican older adults living in community during the first wave of COVID-19 pandemic

Introduction. Loneliness and social isolation are known risk factors for cognitive decline; their effect in older adults (OA) after COVID-19 lockdown is emerging. Objective. To establish an association between loneli-ness and social isolation, with daily cognitive function in Mexican OA during the first wave of the COVID-19 pandemic. Method. Cross-sectional study, derived from the cohort "The impact of COVID 19 on well-being, cognition, and discrimination among older adults in the United States and Latin America", which included 308 OA recruited between March-August 2020 whose daily cognitive function were determined with the Ev-eryday Cognition Scale (E-Cog) as dichotomized score (cut point: 1.31 for normal cognition). Loneliness and social isolation were binomial variables. Results. The mean age was 65.4 t 7.9 years, 75.7% were women. The mean continuous E-Cog score was 57.4 (SD = t 19.1), 49.1% had a score < 1.31 (normal cognition), while 50.9% had a higher score (cognitive impairment). Eighty four percent of participants reported loneli-ness, 79.9% reported social isolation. Multivariate regression model showed a negative and statistically sig-nificant association between social isolation and loneliness and E-Cog, adjusted by age, sex and education level (beta =-.046, 95% CI = [-.8, -.013], p = .007; beta =-.16, 95% CI = [-.08, -.018], p = .003), and a positive association with subjective memory complaint (beta = .81, 95% CI = [-.16,-.11], p = < .001). Discussion and conclusion. These data suggest the need for increased vigilance of those who have loneliness and social isolation due to its potential deleterious effect on cognitive function.