Application of Organoids in Regenerative Medicine

被引：3

作者：

Wu, Yinghua ^{[1
,2
]}

Ye, Wenrui ^{[1
,2
]}

Gao, Yong ^{[3
]}

Yi, Zhenjie ^{[1
,2
]}

Chen, Zhuohui ^{[1
,2
]}

Qu, Chunrun ^{[1
,2
]}

Huang, Jing ^{[4
]}

Liu, Fangkun ^{[5
]}

Liu, Zhixiong ^{[1
,2
,6
]}

机构：

[1] Cent South Univ CSU, Xiangya Hosp, Dept Neurosurg, Changsha, Hunan, Peoples R China

[2] Cent South Univ, Xiangya Hosp, Hypothalam Pituitary Res Ctr, Dept Neurosurg, Changsha, Hunan, Peoples R China

[3] First Peoples Hosp Changde City, Orthoped Dept, Changde, Hunan, Peoples R China

[4] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Dept Psychiat, Changsha, Hunan, Peoples R China

[5] Cent South Univ CSU, Xiangya Hosp, Changsha 410005, Hunan, Peoples R China

[6] Cent South Univ CSU, Xiangya Hosp, Changsha 410005, Hunan, Peoples R China

来源：

STEM CELLS | 2023年 / 41卷 / 12期

基金：

中国国家自然科学基金;

关键词：

organoids; regenerative medicine; transplantation; genetic engineering; pluripotent stem cell; STEM-CELLS; IN-VITRO; CEREBRAL ORGANOIDS; SELF-ORGANIZATION; HUMAN LIVER; TRANSPLANTATION; GENERATION; TISSUE; LONG; MODELS;

D O I：

10.1093/stmcls/sxad072

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Regenerative medicine mainly relies on heterologous transplantation, often hindered by sample availability and ethical issues. Furthermore, patients are required to take immunosuppressive medications to prevent adverse side effects. Stem cell-derived 3D-organoid culture has provided new alternatives for transplantation and regenerative medicine. Scholars have combined organoids with tissue engineering technology to improve reproducibility, the accuracy of constitution and throughput, and genetic correction to achieve a more personalized therapy. Here, we review the available applications of organoids in regenerative medicine and the current challenges concerning this field. Graphical Abstract

引用

页码：1101 / 1112

页数：12

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