Immune checkpoint inhibitors - the revolutionary cancer immunotherapy comes with a cardiotoxic price

被引：6

作者：

Achim, Alexandru ^{[1
,2
,5
]}

Liblik, Kiera ^{[3
]}

Gevaert, Sofie ^{[4
]}

机构：

[1] Kantonsspital Baselland, Med Univ Klin, Klin Kardiol, Liestal, Switzerland

[2] Univ Med & Pharm Iuliu Hatieganu, Niculae Stancioiu Heart Inst, Cluj Napoca, Romania

[3] Queens Univ, Dept Med, Kingston, ON, Canada

[4] Ghent Univ Hosp, Dept Cardiol, Ghent, Belgium

[5] Rheinstr 26, CH-4410 Liestal, Switzerland

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2024年 / 34卷 / 02期

关键词：

Immune checkpoint inhibitors; ICI; Myocarditis; Cardiotoxicity; Adverse events; CARDIOVASCULAR TOXICITIES; CARDIAC EVENTS; MANIFESTATIONS; MYOCARDITIS; MANAGEMENT; OUTCOMES;

D O I：

10.1016/j.tcm.2022.09.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The development of immune checkpoint inhibitors (ICIs) has provided a novel and revolutionary treatment option for previously incurable cancers. However, this major advancement is accompanied by a spectrum of cardiotoxic adverse events that are uncommon but potentially fatal. The oncologic indications of ICIs are becoming increasingly complex, requiring robust clinical monitoring to assess for cardiovascular complications. This is reflected in the recent introduction of the first cardio-oncology guidelines, a sign of the cardiovascular community's recognition that seeks to match this dynamic. The aim of this review is to summarize the cardiac side effects of ICI, with an emphasis on prevalence, diagnosis, and treatment options. (c) 2022 Elsevier Inc. All rights reserved.

引用

页码：71 / 77

页数：7

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