Plant P4-ATPase lipid flippases: How are they regulated?

被引：4
|
作者：
Villagrana, Richard [1 ]
Lopez-Marques, Rosa Laura [1 ]
机构：
[1] Univ Copenhagen, Copenhagen Plant Sci Ctr, Dept Plant & Environm Sci, Frederiksberg, Denmark
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2024年 / 1871卷 / 01期
关键词：
Flippases; P4; ATPases; Autoinhibition; Kinase regulation; Structural modelling; PHOSPHOLIPID FLIPPASE; PROTEIN-KINASES; YEAST; PHOSPHATIDYLSERINE; TRANSLOCATION; ARABIDOPSIS; GOLGI; APOPTOSIS; ATPASES; CASPASE;
D O I：
10.1016/j.bbamcr.2023.119599
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
P4 ATPases are active membrane transporters that translocate lipids towards the cytosolic side of the biological membranes in eukaryotic cells. Due to their essential cellular functions, P4 ATPase activity is expected to be tightly controlled, but fundamental aspects of the regulation of plant P4 ATPases remain unstudied. In this minireview, our knowledge of the regulatory mechanisms of yeast and mammalian P4 ATPases will be summarized, and sequence comparison and structural modelling will be used as a basis to discuss the putative regulation of the corresponding plant lipid transporters.
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页数：7
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