There is a wealth of literature on the relationship between the university and sustainability, but research is still lacking in terms of activating and enhancing its efficiency. Through a literature review, identifying research papers, and conducting an in-depth content analysis of 34 papers, the relationships between the university, sustainability, and academic entrepreneurship were established. Furthermore, a distinction was made between hard and soft research activities, along with the mechanisms that need to be generated within the university to facilitate development. Various types of academic entrepreneurship related to sustainability were identified. Based on the findings, a model is proposed to enhance the dynamism and effectiveness of sustainable academic entrepreneurship in universities. A research agenda is also proposed.