IL-15-dependent immune crosstalk between natural killer cells and dendritic cells in HIV-1 elite controllers

被引：5

作者：

Hartana, Ciputra Adijaya ^{[1
]}

Lancien, Melanie ^{[1
]}

Gao, Ce ^{[1
]}

Rassadkina, Yelizaveta ^{[1
]}

Lichterfeld, Mathias ^{[1
,2
,3
]}

Yu, Xu G. ^{[1
,2
]}

机构：

[1] Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA

[2] Brigham & Womens Hosp, Infect Dis Div, Boston, MA 02115 USA

[3] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

来源：

CELL REPORTS | 2023年 / 42卷 / 12期

关键词：

RNA-SEQ DATA; NK CELL; REPLICATION; ACTIVATION; INDUCTION; INFECTION; MEMORY;

D O I：

10.1016/j.celrep.2023.113530

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

As the principal effector cell population of the innate immune system, natural killer (NK) cells may make crit-ical contributions to natural, immune-mediated control of HIV-1 replication. Using genome-wide assess-ments of activating and inhibitory chromatin features, we demonstrate here that cytotoxic NK (cNK) cells from elite controllers (ECs) display elevated activating histone modifications at the interleukin 2 (IL-2)/IL-15 receptor b chain and the BCL2 gene loci. These histone changes translate into increased responsiveness of cNK cells to paracrine IL-15 secretion, which coincides with higher levels of IL-15 transcription by myeloid dendritic cells in ECs. The distinct immune crosstalk between these innate immune cell populations results in improved IL-15-dependent cNK cell survival and cytotoxicity, paired with a metabolic profile biased toward IL-15-mediated glycolytic activities. Together, these results suggest that cNK cells from ECs display a pro-grammed IL-15 response signature and support the emerging role of innate immune pathways in natural,-free control of HIV-1.

引用

页数：18

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