The Effect of Saffron Kozanis (Crocus sativus L.) Supplementation on Weight Management, Glycemic Markers and Lipid Profile in Adolescents with Obesity: A Double-Blinded Randomized Placebo-Controlled Trial

被引:3
作者
Kotanidou, Eleni P. [1 ]
Tsinopoulou, Vasiliki Rengina [1 ]
Giza, Styliani [1 ]
Ntouma, Stergianna [1 ]
Angeli, Chrysanthi [1 ]
Chatziandreou, Michail [1 ]
Tsopelas, Konstantinos [1 ]
Tseti, Ioulia [2 ]
Galli-Tsinopoulou, Assimina [1 ]
机构
[1] Aristotle Univ Thessaloniki, AHEPA Univ Gen Hosp, Fac Hlth Sci, Dept Paediat 2,Sch Med, Stilponos Kyriakidi 1, Thessaloniki 54636, Greece
[2] Unipharma SA, Kifisia 14564, Greece
来源
CHILDREN-BASEL | 2023年 / 10卷 / 11期
关键词
crocus; saffron; adolescent; youth; obesity; obese; prediabetes; glucose; BMI; insulin; TYPE-2; DIABETES-MELLITUS; CARDIOVASCULAR RISK; GUT MICROBIOME;
D O I
10.3390/children10111814
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Global rates of adolescent obesity have led the World Health Organization to consider the disease a pandemic that needs focus. In search of new anti-obesity agents, Crocus sativus, popularly known as saffron, is a nutraceutical agent, praised for its beneficial effects. The study aimed to investigate the possible effect of Kozanis saffron administration on weight management of obese prediabetic adolescents. Seventy-four obese prediabetic adolescents participated in a double-blind placebo-controlled trial of three arms, randomly assigned to receive either Kozanis saffron (n = 25, 60 mg/day), metformin (n = 25, 1000 mg/day) or a placebo (n = 24), for twelve weeks. Anthropometry, glycemic markers and lipid profiles were investigated at baseline and post-intervention. Saffron supplementation significantly reduced the weight z-score, BMI, BMI z-score and waist circumference (WC) of obese adolescents; however, this reduction was less significant compared to the effect of metformin. Metformin administration offered a significantly more profound improvement in anthropometry compared to saffron administration. Saffron administration also provided significant improvements in weight, weight z-scores, BMI values, BMI z-scores and WCs compared to the placebo. Saffron supplementation failed to change any glycemic marker, but provided a significant reduction in fasting triglyceride levels and also a significant increase in fasting HDL levels. Saffron Kozanis constitutes a promising nutraceutical option for adolescents and children with obesity and prediabetes in need of weight management.
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页数:15
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