BODIPY Based OFF-ON Fluorescent Probe for Endogenous Carbon Monoxide Imaging in Living Cells

被引：2

作者：

Zhao, Lei ^{[1
]}

Chen, Rui ^{[1
]}

Jia, Cheng ^{[1
]}

Liu, Jiandong ^{[1
]}

Liu, Guohua ^{[1
]}

Cheng, Tanyu ^{[1
]}

机构：

[1] Shanghai Normal Univ, Coll Chem & Mat Sci, Shanghai Frontiers Sci Ctr Biomimet Catalysis, Educ Minist,Key Lab Resource Chem, Shanghai 200234, Peoples R China

来源：

JOURNAL OF FLUORESCENCE | 2024年 / 34卷 / 04期

关键词：

Fluorescent probe; BODIPY; Carbon monoxide; Cell imaging; METAL;

D O I：

10.1007/s10895-023-03403-z

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Carbon monoxide (CO) is one of the signaling molecules that are ubiquitous in humans, which involves in the regulation of human physiology and pathology. In this work, the probe PEC was designed and synthesized based on BODIPY fluorophore that can selectively detect CO through reducing the nitro group to amino group, resulting in a "turn-on" fluorescence response with a simultaneous increase in the concentration of CO. The response is selective over a variety of relevant reactive free radicals, ions, and amino acid species. PEC has the advantages of good stability, good water solubility, and obvious changes in fluorescence signals. In addition, PEC can be used to detect and track endogenous CO in living cells.

引用

页码：1793 / 1799

页数：7

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