Many kinases for controlling the water channel aquaporin-2

被引：7

作者：

Kharin, Andrii ^{[1
]}

Klussmann, Enno ^{[1
,2
]}

机构：

[1] Max Delbruck Ctr Mol Med Helmholtz Assoc MDC, Berlin, Germany

[2] DZHK German Ctr Cardiovasc Res, Berlin, Germany

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2024年 / 602卷 / 13期

关键词：

NEPHROGENIC DIABETES-INSIPIDUS; RENAL COLLECTING DUCT; VASOPRESSIN-MEDIATED TRANSLOCATION; CEREBRAL-ARTERY OCCLUSION; A ANCHORING PROTEINS; BRAIN EDEMA; REACTIVE ASTROCYTES; MEMBRANE INSERTION; CELL-MEMBRANES; INFARCT VOLUME;

D O I：

10.1113/JP284100

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Aquaporin-2 (AQP2) is amember of the aquaporinwater channel family. In the kidney, AQP2 is expressed in collecting duct principal cells where it facilitates water reabsorption in response to antidiuretic hormone (arginine vasopressin, AVP). AVP induces the redistribution of AQP2 from intracellular vesicles and its incorporation into the plasmamembrane. The plasma membrane insertion of AQP2 represents the crucial step in AVP-mediated water reabsorption. Dysregulation of the system preventing the AQP2 plasma membrane insertion causes diabetes insipidus (DI), a disease characterised by an impaired urine concentrating ability and polydipsia. There is no satisfactory treatment of DI available. This review discusses kinases that control the localisation of AQP2 and points out potential kinase-directed targets for the treatment of DI.

引用

页码：3025 / 3039

页数：15

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