Two new anti-inflammatory compounds from the roots and rhizomes of Clematis terniflora var. manshurica (Rupr.) Ohwi

被引：1

作者：

Shao, Ping ^{[1
,2
]}

Dong, Sheng ^{[1
]}

Mu, Lin-Tong ^{[1
]}

Han, Ling ^{[2
]}

Lv, Chong-Ning ^{[1
]}

Yuan, Jiu-Zhi ^{[1
]}

Lu, Jin-Cai ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Materia Med, Dept Pharmaceut Bot & Authenticat TCM, Shenyang, Peoples R China

[2] NERC Pharmaceut Tradit Chinese Med, Res & Dev Ctr, Benxi, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2024年 / 38卷 / 11期

关键词：

Clematis terniflora var. manshurica (Rupr) Ohwi; chemical composition; anti-inflammatory activity; TRITERPENE SAPONINS; LIGNANS;

D O I：

10.1080/14786419.2023.2227912

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new compounds named mandshurica A (1) and mandshurica B (2), together with four known lignans (3-6) were isolated from the roots and rhizomes of Clematis terniflora var. manshurica (Rupr.) Ohwi. The structures of the new compounds were elucidated by HR-ESI-MS, 1D and 2D NMR spectroscopy. Moreover, the anti-inflammatory activity of compounds 1 and 2 were evaluated against lipopolysaccharide-induced mouse macrophage RAW264.7 cells. Compounds 1 and 2 displayed significant inhibitory effect on NO production, and compound 2 exhibited obvious inhibition on the pro-inflammatory cytokines TNF-& alpha;. Both new compounds showed potential anti-inflammatory activity.

引用

页码：1874 / 1881

页数：8

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