Macitentan treatment of portopulmonary hypertension with hepatopulmonary syndrome: a case report and literature review

被引：0

作者：

Li, Niuniu ^{[1
]}

Wu, Qiang ^{[1
]}

Meng, Juan ^{[1
]}

Feng, Cheng ^{[1
]}

Jiang, Siwei ^{[1
]}

Chen, Meixia ^{[1
]}

Xu, Wenhui ^{[1
]}

Wang, Fei ^{[1
]}

Zhang, Yifan ^{[1
]}

Liu, Juncai ^{[1
]}

Xu, Cheng ^{[1
]}

Liu, Gaolin ^{[2
]}

Gao, Hong ^{[1
,3
]}

机构：

[1] Shenzhen Third Peoples Hosp, Dept Geriatr Med, Shenzhen, Peoples R China

[2] Washington Univ St Louis, St. Louis, MO USA

[3] Shenzhen Third Peoples Hosp, Dept Geriatr Med, 29 Buji Bulan Rd, Shenzhen 518112, Guangdong Provi, Peoples R China

来源：

ESC HEART FAILURE | 2023年 / 10卷 / 04期

关键词：

Hepatopulmonary syndrome; Liver failure; Macitentan; Portopulmonary hypertension; PULMONARY ARTERIAL-HYPERTENSION; EFFICACY; SAFETY;

D O I：

10.1002/ehf2.14431

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pulmonary arterial hypertension-targeted therapies in portopulmonary hypertension (PoPH) are scarce, let alone for patients with chronic liver failure (CLF) and hepatopulmonary syndrome (HPS). A 48-year male was admitted to the hospital because of cirrhosis for 18 years, systemic oedema, and chest distress after exercise for 1 week. He was diagnosed with CLF, PoPH, and HPS. After 7 weeks of macitentan treatment, the patient's activity tolerance, pulmonary artery systolic pressure, arterial partial pressure of oxygen (PaO2), cTNI, and NT-proBNP changes indicated gradual recovery, without hepatic safety concerns. This case indicated that administering macitentan in patients diagnosed as PoPH (with CLF and HPS) may be efficient and safe enough in a clinical setting.

引用

页码：2718 / 2721

页数：4

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