Soluble Urokinase Plasminogen Activator Receptor (suPAR) in Autoimmune Rheumatic and Non Rheumatic Diseases

被引：4

作者：

Manfredi, Mariangela ^{[1
]}

Van Hoovels, Lieve ^{[2
,3
]}

Benucci, Maurizio ^{[4
]}

De Luca, Riccardo ^{[5
]}

Coccia, Carmela ^{[5
]}

Bernardini, Pamela ^{[5
]}

Russo, Edda ^{[5
]}

Amedei, Amedeo ^{[5
]}

Guiducci, Serena ^{[5
]}

Grossi, Valentina ^{[1
]}

Bossuyt, Xavier ^{[2
,6
]}

Perricone, Carlo ^{[7
]}

Infantino, Maria ^{[1
]}

机构：

[1] S Giovanni Dio Hosp, Immunol & Allergol Lab Unit, I-50143 Florence, Italy

[2] Univ Leuven, Dept Microbiol Immunol & Transplantat, B-3000 Leuven, Belgium

[3] Onze Lieve Vrouw Hosp, Dept Lab Med, B-9300 Aalst, Belgium

[4] S Giovanni Dio Hosp, Rheumatol Unit, I-50143 Florence, Italy

[5] Univ Florence, Dept Clin & Expt Med, I-50139 Florence, Italy

[6] Univ Hosp Leuven, Dept Lab Med, B-3000 Leuven, Belgium

[7] Univ Perugia, Dept Med & Surg, Rheumatol Unit, I-06122 Perugia, Italy

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2023年 / 13卷 / 04期

关键词：

suPAR; rheumatoid arthritis; autoimmune diseases; rheumatic diseases; C-REACTIVE PROTEIN; FECAL CALPROTECTIN; HEALTHY DONORS; SERUM-LEVELS; PLASMA; INFLAMMATION; LUPUS; ASSOCIATION; ARTHRITIS; CANCER;

D O I：

10.3390/jpm13040688

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

The soluble urokinase plasminogen activator receptor (suPAR) is the bioactive form of uPAR, a membrane-bound glycoprotein, and it is primarily expressed on the surface of immunologically active cells. Mirroring local inflammation and immune activation, suPAR has gained interest as a potential prognostic biomarker in several inflammatory diseases. Indeed, in many diseases, including cancer, diabetes, cardiovascular diseases, kidney diseases, and inflammatory disorders, higher suPAR concentrations have been associated with disease severity, disease relapse, and mortality. Our review describes and discusses the supporting literature concerning the promising role of suPAR as a biomarker in different autoimmune rheumatic and non-rheumatic diseases.

引用

页数：12

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