Hospitalization Rates for Inflammatory Bowel Disease Are Decreasing Over Time: A Population-based Cohort Study

被引：8

作者：

Buie, Michael J. ^{[1
,2
]}

Coward, Stephanie ^{[1
,2
]}

Shaheen, Abdel-Aziz ^{[1
,2
]}

Holroyd-Leduc, Jayna ^{[1
,2
]}

Hracs, Lindsay ^{[1
,2
]}

Ma, Christopher ^{[1
,3
]}

Panaccione, Remo ^{[2
,3
]}

Benchimol, Eric, I ^{[4
,5
,6
,7
,8
]}

Bernstein, Charles N. ^{[9
,10
]}

Bitton, Alain ^{[11
,12
]}

Otley, Anthony R. ^{[13
]}

Jones, Jennifer L. ^{[14
]}

Murthy, Sanjay K. ^{[15
,16
,17
,18
]}

Ellen Kuenzig, M. ^{[4
]}

Pena-Sanchez, Juan-Nicolas ^{[19
]}

Targownik, Laura E. ^{[20
]}

Singh, Harminder ^{[21
,22
]}

Avina-Zubieta, Antonio ^{[23
]}

Kaplan, Gilaad G. ^{[1
,2
]}

机构：

[1] Univ Calgary, Dept Med, Calgary, AB, Canada

[2] Univ Calgary, Dept Community Hlth Sci, Calgary, AB, Canada

[3] Univ Calgary, Dept Med, Div Gastroenterol & Hepatol, Calgary, AB, Canada

[4] Hosp Sick Children, SickKids Inflammatory Bowel Dis Ctr, Div Gastroenterol Hepatol & Nutr, Toronto, ON, Canada

[5] SickKids Res Inst, Child Hlth Evaluat Sci, Toronto, ON, Canada

[6] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada

[7] Inst Clin Evaluat Sci, Toronto, ON, Canada

[8] Univ Toronto, Dept Paediat, Toronto, ON, Canada

[9] Univ Manitoba, Dept Med, Winnipeg, MB, Canada

[10] Univ Manitoba, Rady Fac Hlth Sci, Max Rady Coll Med, IBD Clin & Res Ctr, Winnipeg, MB, Canada

[11] McGill Univ, Div Gastroenterol & Hepatol, Montreal, PQ, Canada

[12] McGill Univ, Hlth Ctr, Montreal, PQ, Canada

[13] Dalhousie Univ, Fac Med, Dept Pediat, Halifax, NS T2N 4Z6, Canada

[14] Dalhousie Univ, Dept Med, Div Digest Care & Endoscopy, Halifax, NS, Canada

[15] Univ Ottawa, Dept Med, Ottawa, ON, Canada

[16] Ottawa Hosp IBD Ctr, Div Gastroenterol, Ottawa, ON, Canada

[17] Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada

[18] Univ Ottawa, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada

[19] Univ Saskatchewan, Coll Med, Dept Community Hlth & Epidemiol, Saskatoon, SK, Canada

[20] Mt Sinai Hlth, Zane Cohen Ctr Digest Dis, Toronto, ON, Canada

[21] Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Dept Med & Community Hlth Sci, Winnipeg, MB, Canada

[22] Res Inst, CancerCare, Winnipeg, MB, Canada

[23] Univ British Columbia, Div Rheumatol, Dept Med, Vancouver, BC, Canada

来源：

INFLAMMATORY BOWEL DISEASES | 2023年 / 29卷 / 10期

关键词：

inflammatory bowel disease; Crohn's disease; ulcerative colitis; hospitalization rates; epidemiology; CROHNS-DISEASE; VALIDATION; SURGERY; RISK; CARE;

D O I：

10.1093/ibd/izad020

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background Recent advances in the management of inflammatory bowel disease (IBD) striving for new treatment targets may have decreased rates of hospitalization for flares. We compared all-cause, IBD-related, and non-IBD-related hospitalizations while accounting for the rising prevalence of IBD. Methods Population-based, administrative health care databases identified all individuals living with IBD in Alberta between fiscal year 2002 and 2018. Hospitalization rates (all-cause, IBD-related, and non-IBD-related) were calculated using the prevalent Alberta IBD population. Hospitalizations were stratified by disease type, age, sex, and metropolitan status. Data were age and sex standardized to the 2019 Canadian population. Log-linear models calculated Average Annual Percentage Change (AAPC) in hospitalization rates with associated 95% confidence intervals (CIs). Results From 2002-2003 to 2018-2019, all-cause hospitalization rates decreased from 36.57 to 16.72 per 100 IBD patients (AAPC, -4.18%; 95% CI, -4.69 to -3.66). Inflammatory bowel disease-related hospitalization rate decreased from 26.44 to 9.24 per 100 IBD patients (AAPC, -5.54%; 95% CI, -6.19 to -4.88). Non-IBD-related hospitalization rate decreased from 10.13 to 7.48 per 100 IBD patients (AAPC, -1.82%; 95% CI, -2.14 to -1.49). Those over 80 years old had the greatest all-cause and non-IBD-related hospitalization rates. Temporal trends showing decreasing hospitalization rates were observed across age, sex, IBD type, and metropolitan status. Conclusions Hospitalization rates are decreasing for all-cause, IBD-related, and non-IBD-related hospitalizations. Over the past 20 years, the care of IBD has transitioned from hospital-based care to ambulatory-centric IBD management. Lay Summary Hospitalization rates per 100 IBD patients are decreasing. However, when using the general population as the denominator, the interpretation of temporal trends changes because the prevalence of IBD has risen faster than the general population's growth rate.

引用

页码：1536 / 1545

页数：10

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