Arterial myogenic response and aging

被引：5

作者：

Cui, Yingqiu ^{[1
]}

Gollasch, Maik ^{[2
]}

Kassmann, Mario ^{[2
]}

机构：

[1] Charite Univ Med Berlin, Expt & Clin Res Ctr ECRC, Lindenberger Weg 80, D-13125 Berlin, Germany

[2] Univ Med Greifswald, Dept Internal Med & Geriatr, Felix Hausdorff Str 3, D-17487 Greifswald, Germany

来源：

AGEING RESEARCH REVIEWS | 2023年 / 84卷

关键词：

Myogenic response; Aging; Vascular smooth muscle; Ion channels; SMOOTH-MUSCLE-CELLS; II TYPE-1 RECEPTOR; ENDOTHELIUM-DEPENDENT VASODILATION; PERIVASCULAR ADIPOSE-TISSUE; FLOW-MEDIATED DILATION; AGE-RELATED IMPAIRMENT; ANGIOTENSIN-II; BLOOD-PRESSURE; TRPV4; CHANNELS; RYANODINE RECEPTORS;

D O I：

10.1016/j.arr.2022.101813

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The arterial myogenic response is an inherent property of resistance arteries. Myogenic tone is crucial for maintaining a relatively constant blood flow in response to changes in intraluminal pressure and protects delicate organs from excessive blood flow. Although this fundamental physiological phenomenon has been extensively studied, the underlying molecular mechanisms are largely unknown. Recent studies identified a crucial role of mechano-activated angiotensin II type 1 receptors (AT1R) in this process. The development of myogenic response is affected by aging. In this review, we summarize recent progress made to understand the role of AT1R and other mechanosensors in the control of arterial myogenic response. We discuss age-related alterations in myogenic response and possible underlying mechanisms and implications for healthy aging.

引用

页数：10

共 188 条

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