pH and its applications in targeted drug delivery

被引：39
作者：
Abdella, Sadikalmahdi [1 ,2 ]
Abid, Fatima [1 ]
Youssef, Souha H. [1 ]
Kim, Sangseo [1 ]
Afinjuomo, Franklin [1 ]
Malinga, Constance [1 ]
Song, Yunmei [1 ]
Garg, Sanjay [1 ]
机构：
[1] Univ South Australia, Ctr Pharmaceut Innovat CPI, Adelaide, SA 5000, Australia
[2] Addis Ababa Univ, Coll Hlth Sci, Dept Pharmacol, Clin Pharm, Zambia St, Addis Ababa, Ethiopia
来源：
DRUG DISCOVERY TODAY | 2023年 / 28卷 / 01期
关键词：
pH-sensitive; targeted drug delivery; formulations; diseases; acidic; alkaline; STRATUM-CORNEUM HYDRATION; SKIN SURFACE PH; IN-VITRO; HYALURONIC-ACID; POLYMERIC NANOPARTICLES; CHITOSAN NANOPARTICLES; COATED NANOPARTICLES; LIPID NANOPARTICLES; CONTROLLED-RELEASE; TRIGGERED RELEASE;
D O I：
10.1016/j.drudis.2022.103414
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Physiologic pH is vital for the normal functioning of tissues and varies in different parts of the body. The varying pH of the body has been exploited to design pH -sensitive smart oral, transdermal and vaginal drug delivery systems (DDS). The DDS demonstrated promis-ing results in hard-to-treat diseases such as cancer and Helicobacter pylori infection. In some cases, a change in pH of tissues or body fluids has also been employed as a useful diagnostic biomarker. This paper aims to com-prehensively review the development and applications of pH-sensitive DDS as well as recent advances in the field.
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页数：18
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