Platelet membrane-coated C-TiO2 hollow nanospheres for combined sonodynamic and alkyl-radical cancer therapy

被引:42
作者
Guo, Weihong [4 ,5 ]
Wang, Tao [2 ]
Huang, Chunyu [1 ,6 ]
Ning, Shipeng [7 ]
Guo, Qinglong [2 ]
Zhang, Wei [3 ]
Yang, Huawei [7 ]
Zhu, Daoming [4 ,5 ]
Huang, Qinqin [1 ]
Qian, Haisheng [3 ]
Wang, Xianwen [3 ]
机构
[1] Zhengzhou Univ, Dept Mol Pathol, Affiliated Hosp 2, Zhengzhou 450014, Peoples R China
[2] Anhui Med Univ, Dept Orthopaed, Hosp 2, Hefei 230601, Peoples R China
[3] Anhui Med Univ, Res & Engn Ctr Biomed Mat, Sch Biomed Engn, Hefei 230032, Peoples R China
[4] Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Dept Gen Surg, Guangzhou 510515, Peoples R China
[5] Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Guangdong Prov Key Lab Precis Med Gastrointestina, Guangzhou 510515, Peoples R China
[6] Wuhan Univ, Hubei Canc Clin Study Ctr, Dept Radiat & Med Oncol, Hubei Key Lab Tumor Biol Behav,Zhongnan Hosp, Wuhan 430071, Peoples R China
[7] Guangxi Med Univ, Dept Breast Surg, Canc Hosp, Nanning 530000, Peoples R China
关键词
C-TiO2; sonodynamic therapy; alkyl-radical therapy; combination therapy; biomimetic nanomaterials;
D O I
10.1007/s12274-022-4646-2
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
The therapeutic efficiency of sonodynamic therapy (SDT) mainly depends on the presence of oxygen (O-2) to generate harmful reactive oxygen species (ROS); thus, the hypoxic tumor microenvironment significantly limits the efficacy of SDT. Therefore, the development of oxygen-independent free radical generators and associated combination therapy tactics can be a promising field to facilitate the anticancer capability of SDT. In this study, a biomimetic drug delivery system (C-TiO2/AIPH@PM) composed of an alkyl-radical generator (2,2 '-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride, AIPH)-loaded C-TiO2 hollow nanoshells (HNSs) as the inner cores, and a platelet membrane (PM) as the outer shells is successfully prepared for synergistic SDT and oxygen-independent alkyl-radical therapy. The PM encapsulation can significantly prolong the blood circulation time of C-TiO2/AIPH@PM compared with C-TiO2/AIPH while enabling C-TiO2/AIPH@PM to achieve tumor targeting. C-TiO2/AIPH@PM can efficiently produce ROS and alkyl radicals, which can achieve a more thorough tumor eradication regardless of the normoxic or hypoxic conditions. Furthermore, the generation of these radicals improves the efficiency of SDT. In addition, nitrogen (N-2) produced due to the decomposition of AIPH enhances the acoustic cavitation effect and lowers the cavitation threshold, thereby enhancing the penetration of C-TiO2/AIPH@PM at the tumor sites. Both in vitro and in vivo experiments demonstrate that C-TiO2/AIPH@PM possesses good biosafety, ultrasound imaging performance, and excellent anticancer efficacy. This study provides a new strategy to achieve oxygen-independent free radical production and enhance therapeutic efficacy by combining SDT and free radical therapy.
引用
收藏
页码:782 / 791
页数:10
相关论文
共 50 条
[1]   TiO2 Nanosheets with the Au Nanocrystal-Decorated Edge for Mitochondria-Targeting Enhanced Sonodynamic Therapy [J].
Cao, Yu ;
Wu, Tingting ;
Dai, Wenhao ;
Dong, Haifeng ;
Zhang, Xueji .
CHEMISTRY OF MATERIALS, 2019, 31 (21) :9105-9114
[2]   In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy [J].
Fan, Kelong ;
Xi, Juqun ;
Fan, Lei ;
Wang, Peixia ;
Zhu, Chunhua ;
Tang, Yan ;
Xu, Xiangdong ;
Liang, Minmin ;
Jiang, Bing ;
Yan, Xiyun ;
Gao, Lizeng .
NATURE COMMUNICATIONS, 2018, 9
[3]   Smart Drug Delivery Systems Based on DNA Nanotechnology [J].
Fan, Qin ;
He, Zhimei ;
Xiong, Jinxin ;
Chao, Jie .
CHEMPLUSCHEM, 2022, 87 (03)
[4]   Platinum Crosslinked Carbon Dot@TiO2-x p-n Junctions for Relapse-Free Sonodynamic Tumor Eradication via High-Yield ROS and GSH Depletion [J].
Geng, Bijiang ;
Xu, Shuang ;
Li, Ping ;
Li, Xiaokai ;
Fang, Fuling ;
Pan, Dengyu ;
Shen, Longxiang .
SMALL, 2022, 18 (06)
[5]   Engineering Cu-CuFe2O4 nanoenzyme for hypoxia-relief and GSH-depletion enhanced chemodynamic/sonodynamic therapy [J].
Gong, Chenchen ;
Zhao, Jianming ;
Meng, Xiangdan ;
Yang, Zhou ;
Dong, Haifeng .
CHEMICAL ENGINEERING JOURNAL, 2022, 435
[6]   Tumor Metabolism-Engineered Composite Nanoplatforms Potentiate Sonodynamic Therapy via Reshaping Tumor Microenvironment and Facilitating Electron-Hole Pairs' Separation [J].
Guan, Xin ;
Yin, Hao-Hao ;
Xu, Xiao-Hong ;
Xu, Guang ;
Zhang, Yan ;
Zhou, Bang-Guo ;
Yue, Wen-Wen ;
Liu, Chang ;
Sun, Li-Ping ;
Xu, Hui-Xiong ;
Zhang, Kun .
ADVANCED FUNCTIONAL MATERIALS, 2020, 30 (27)
[7]   Nanosensitizers for sonodynamic therapy for glioblastoma multiforme: current progress and future perspectives [J].
Guo, Qing-Long ;
Dai, Xing-Liang ;
Yin, Meng-Yuan ;
Cheng, Hong-Wei ;
Qian, Hai-Sheng ;
Wang, Hua ;
Zhu, Dao-Ming ;
Wang, Xian-Wen .
MILITARY MEDICAL RESEARCH, 2022, 9 (01)
[8]   Oxygen-Deficient Black Titania for Synergistic/Enhanced Sonodynamic and Photoinduced Cancer Therapy at Near Infrared-II Biowindow [J].
Han, Xiaoxia ;
Huang, Ju ;
Jing, Xiangxiang ;
Yang, Dayan ;
Lin, Han ;
Wang, Zhigang ;
Li, Pan ;
Chen, Yu .
ACS NANO, 2018, 12 (05) :4545-4555
[9]   Oxygen-carrying microfluidic microcapsules for enhancing chemo-sonodynamic therapy on patient-derived tumor organoid models [J].
Huang, Danqing ;
Zhao, Cheng ;
Wen, Baojie ;
Fu, Xiao ;
Shang, Luoran ;
Kong, Wentao ;
Zhao, Yuanjin .
CHEMICAL ENGINEERING JOURNAL, 2022, 435
[10]   Magnetothermally Triggered Free-Radical Generation for Deep-Seated Tumor Treatment [J].
Huang, Guoming ;
Qiu, Yuan ;
Yang, Feifei ;
Xie, Jiangao ;
Chen, Xin ;
Wang, Lili ;
Yang, Huanghao .
NANO LETTERS, 2021, 21 (07) :2926-2931