Enhanced neuronal differentiation using plasma synthesized amino polymers

被引：0

作者：

Munoz, Estephanny Jocelyn Alvarado ^{[1
]}

Gonzalez, Roberto Olayo ^{[2
]}

Gonzalez, Maria Guadalupe Olayo ^{[3
]}

Cruz, Guillermo Jesus Cruz ^{[3
]}

Juarez, Omar Eduardo Uribe ^{[1
]}

Salgado, Angelica Coyoy ^{[4
]}

Fong, Daniel Martinez ^{[5
]}

Ceballos, Hermelinda Salgado ^{[4
]}

Barrios, Carlos Enrique Orozco ^{[4
]}

Corona, Juan Morales ^{[2
]}

机构：

[1] Univ Autonoma Metropolitana, Dept Elect Engn, Postgrad Biomed Engn, Mexico City, Mexico

[2] Univ Autonoma Metropolitana, Dept Phys, Mexico City, Mexico

[3] Inst Nacl Invest Nucl, Dept Phys, Ocoyoacac, Mexico

[4] Inst Mexicano Seguro Social, Conacyt Neurol Dis Med Res Unit, Mexico City, Mexico

[5] Natl Polytech Inst, Ctr Res & Adv Studies, Mexico City, Mexico

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2025年 / 74卷 / 01期

关键词：

Biopolymers; plasma polymerization; polypyrrole; polyallylamine; SPINAL-CORD-INJURY; FUNCTIONAL-GROUPS; CELLS; PYRROLE; POLYPYRROLE; SURFACES; RATS; POLYMERIZATION; IMPLANTS; RECOVERY;

D O I：

10.1080/00914037.2024.2312824

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Different pyrrole and allylamine polymeric materials, were synthesized by plasma polymerization with different powers and doped with iodine. The polymers were characterized physicochemically. A cell line of neuronal origin (N1E-115) was cultured on them to evaluate the effects of the materials on neuronal differentiation. Following a differentiation stimulus, immunofluorescence was performed, and the lengths of neurites, as well as the complexity of the network formed and the number of nuclei, were measured and analyzed to provide a differentiation index. The results showed that the polymeric materials exhibited different physicochemical characteristics depending on the synthesis conditions and enhanced neuronal differentiation.

引用

页码：11 / 20

页数：10

共 37 条

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