Targeting neutrophils: Mechanism and advances in cancer therapy

BackgroundCancer is a thorny problem which cannot be conquered by mankind at present and recent researchers have put their focus on tumor microenviroment. Neutrophils, the prominent leukocytes in peripheral blood that accumulate in tumours, serves as frontline cells in response to tumour progression owing to the rapid development of micro biotechnology. Hence, targeted therapy with these neutrophils has made targeting treatment a promising field in cancer therapy.Main bodyWe broadly summarise some studies on the phenotypes and functions of tumour-associated neutrophils as well as the unique web-like products of neutrophils that play a role in cancer progression-neutrophil extracellular traps-and the interactions between neutrophils and the tumour microenvironment. Moreover, several targeted neutrophils therapeutic studies have made some progress and provided potential strategies for the treatment of cancer.ConclusionThis review aims to offer a holistic perspective on therapeutic interventions targeting neutrophils to further inspire more researches on cancer therapies. Our discussion predominantly centred on the distinctive role of neutrophils within the tumour microenvironment and the prospect of devising targeted therapies. Neutrophil extracellular traps play a pivotal role in contemporary cancer research which also become a subject extensively covered in our essay. At last, we provided a summary of ongoing therapies aimed at targeting neutrophils and illuminated potential therapeutic targets. image