Improved physicochemical stability of fish oil nanoemulsion via a dense interfacial layer formed by hyaluronic acid-poly(glyceryl)10-stearate

被引：4

作者：

Ao, Sha ^{[1
,2
]}

Luo, Xiang ^{[1
,2
]}

Wu, Hongze ^{[1
,2
]}

Zhou, Yanyan ^{[1
]}

Yang, Qun ^{[3
]}

Yin, Xuguang ^{[1
]}

Fu, Hongliang ^{[1
]}

Huang, Mengyu ^{[2
]}

Lu, Dandan ^{[2
]}

Zhu, Kewu ^{[1
]}

机构：

[1] Shaoxing Univ, Ctr Drug Delivery Syst Res, Sch Med, 900 Chengnan Ave, Shaoxing 312000, Zhejiang, Peoples R China

[2] Shaoxing Univ, Zhejiang Engn Res Ctr Fat Soluble Vitamin, Sch Chem & Chem Engn, 900 Chengnan Ave, Shaoxing 312000, Zhejiang, Peoples R China

[3] Shaoxing Univ, Yuanpei Coll, Sch Med & Hlth, 2799 Qunxian Middle Rd, Shaoxing 312000, Zhejiang, Peoples R China

来源：

FOOD CHEMISTRY | 2024年 / 444卷

关键词：

Hyaluronic acid; Poly(glyceryl); Nanoemulsions; Surface density; Freeze-thaw stability; IN-WATER EMULSIONS; CHEMICAL-STABILITY; DELIVERY-SYSTEMS; IMPACT; ENCAPSULATION; POLYGLYCEROL; TEMPERATURE; FABRICATION; VITRO; PH;

D O I：

10.1016/j.foodchem.2024.138585

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This study aimed to synthesize a novel emulsifier, hyaluronic acid-poly(glyceryl)10-stearate (HA-PG10-C18), and employ it for the fabrication of nanoemulsions incorporating deep-sea fish oil to improve their apparent solubility and physicochemical stability. 1H NMR and FT-IR analyses indicated successful synthesis of HA-PG10-C18. Nanoemulsions of deep-sea fish oil loaded with HA-PG10-C18 (HA-PG10-C18@NE) were successfully fabricated by ultrasonic emulsification. The fixed aqueous layer thickness (FALT) of PG10-C18@NE and HA-PG10-C18@NE was determined and the FALT of both nanoemulsions was similar, while the surface density of HA-PG10C18@NE (4.92 x 10-12 ng/nm2) is 60 % higher than that of PG10-C18@NE (3.07 x 10-12 ng/nm2). Notably, HA-PG10-C18@NE demonstrated an exceptional physicochemical stability when exposed to various stressed environmental conditions, especially its freeze-thaw stability. Moreover, after simulated in vitro digestion, the HA-PG10-C18@NE exhibited a comparatively greater liberation of free fatty acids (94.0 +/- 1.7 %) when compared to the release observed in PG10-C18@NE (85.5 +/- 2.2 %).

引用

页数：14

共 54 条

[1] Carbon nanotubes-graft-polyglycerol: Biocompatible hybrid materials for nanomedicine [J].