Recent Progress in Retinal Pigment Epithelium Cell-Based Therapy for Retinal Disease

被引：8

作者：

Klymenko, Valeriia ^{[1
]}

Martinez, Orlando G. Gonzalez ^{[1
]}

Zarbin, Marco ^{[1
,2
]}

机构：

[1] Rutgers State Univ, Rutgers New Jersey Med Sch, Inst Ophthalmol & Visual Sci, Newark, NJ 07103 USA

[2] Rutgers New Jersey Med Sch, 90 Bergen St, Suite 6100, Newark, NJ 07103 USA

来源：

STEM CELLS TRANSLATIONAL MEDICINE | 2024年 / 13卷 / 04期

关键词：

geographic atrophy; macular degeneration; induced pluripotent stem cells; embryonic stem cells; cell transplantation; retina; retinal pigment epithelium; retinitis pigmentosa; OPTICAL COHERENCE TOMOGRAPHY; PLURIPOTENT STEM-CELLS; MACULAR DEGENERATION; GEOGRAPHIC ATROPHY; SUBRETINAL IMPLANTATION; TRANSPORTER GENE; BRUCHS MEMBRANE; HUMAN RPE; TRANSPLANTATION; GENERATION;

D O I：

10.1093/stcltm/szae004

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Age-related macular degeneration and retinitis pigmentosa are degenerative retinal diseases that cause severe vision loss. Early clinical trials involving transplantation of retinal pigment epithelial cells and/or photoreceptors as a treatment for these conditions are underway. In this review, we summarize recent progress in the field of retinal pigment epithelium transplantation, including some pertinent clinical trial results as well as preclinical studies that address issues of transplant immunology, cell delivery, and cell manufacturing. Graphical Abstract

引用

页码：317 / 331

页数：15

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