Recent Progress in Retinal Pigment Epithelium Cell-Based Therapy for Retinal Disease

被引：8

作者：

Klymenko, Valeriia ^{[1
]}

Martinez, Orlando G. Gonzalez ^{[1
]}

Zarbin, Marco ^{[1
,2
]}

机构：

[1] Rutgers State Univ, Rutgers New Jersey Med Sch, Inst Ophthalmol & Visual Sci, Newark, NJ 07103 USA

[2] Rutgers New Jersey Med Sch, 90 Bergen St, Suite 6100, Newark, NJ 07103 USA

来源：

STEM CELLS TRANSLATIONAL MEDICINE | 2024年 / 13卷 / 04期

关键词：

geographic atrophy; macular degeneration; induced pluripotent stem cells; embryonic stem cells; cell transplantation; retina; retinal pigment epithelium; retinitis pigmentosa; OPTICAL COHERENCE TOMOGRAPHY; PLURIPOTENT STEM-CELLS; MACULAR DEGENERATION; GEOGRAPHIC ATROPHY; SUBRETINAL IMPLANTATION; TRANSPORTER GENE; BRUCHS MEMBRANE; HUMAN RPE; TRANSPLANTATION; GENERATION;

D O I：

10.1093/stcltm/szae004

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Age-related macular degeneration and retinitis pigmentosa are degenerative retinal diseases that cause severe vision loss. Early clinical trials involving transplantation of retinal pigment epithelial cells and/or photoreceptors as a treatment for these conditions are underway. In this review, we summarize recent progress in the field of retinal pigment epithelium transplantation, including some pertinent clinical trial results as well as preclinical studies that address issues of transplant immunology, cell delivery, and cell manufacturing. Graphical Abstract

引用

页码：317 / 331

页数：15

共 50 条

[21] Stem cell-derived retinal pigment epithelium cell therapy: Past and future directions
Rohowetz, Landon J. J.
Koulen, Peter
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2023, 11
[22] Human Umbilical Tissue-Derived Cells Rescue Retinal Pigment Epithelium Dysfunction in Retinal Degeneration
Cao, Jing
Murat, Christopher
An, Weijun
Yao, Xiang
Lee, John
Santulli-Marotto, Sandra
Harris, Ian R.
Inana, George
STEM CELLS, 2016, 34 (02) : 367 - 379
[23] Interactions of the choroid, Bruch's membrane, retinal pigment epithelium, and neurosensory retina collaborate to form the outer blood-retinal-barrier
Fields, Mark A.
Del Priore, Lucian V.
Adelman, Ron A.
Rizzolo, Lawrence J.
PROGRESS IN RETINAL AND EYE RESEARCH, 2020, 76
[24] Impact of drusen and drusenoid retinal pigment epithelium elevation size and structure on the integrity of the retinal pigment epithelium layer
Schlanitz, Ferdinand
Baumann, Bernhard
Sacu, Stefan
Baumann, Lukas
Pircher, Michael
Hitzenberger, Christoph K.
Schmidt-Erfurth, Ursula Margarethe
BRITISH JOURNAL OF OPHTHALMOLOGY, 2019, 103 (02) : 227 - 232
[25] Formation and growth of lipofuscin in the retinal pigment epithelium cells
Mazzitello, K. I.
Arizmendi, C. M.
Family, F.
Grossniklaus, H. E.
PHYSICAL REVIEW E, 2009, 80 (05)
[26] Retinal Pigment Epithelium Regeneration by Induced Pluripotent Stem Cells; Therapeutic and Modelling Approaches on Retinal Degenerative Diseases
Setayeshi, Shadi
Rasoulinejad, Seyed Ahmad
CURRENT STEM CELL RESEARCH & THERAPY, 2021, 16 (06) : 710 - 717
[27] Stem cell-derived retinal pigment epithelium transplantation for treatment of retinal disease
Nommiste, Britta
Fynes, Kate
Tovell, Victoria E.
Ramsden, Conor
da Cruz, Lyndon
Coffey, Peter
FUNCTIONAL NEURAL TRANSPLANTATION IV: TRANSLATION TO CLINICAL APPLICATION, PT B, 2017, 231 : 225 - 244
[28] Factors Affecting Stem Cell-Based Regenerative Approaches in Retinal Degeneration
Patel, Sachin H.
Lamba, Deepak A.
ANNUAL REVIEW OF VISION SCIENCE, 2023, 9 : 155 - 175
[29] RETINAL PIGMENT EPITHELIUM APERTURE A Previously Unreported Finding in the Evolution of Avascular Pigment Epithelium Detachment
Querques, Giuseppe
Capuano, Vittorio
Costanzo, Eliana
Corvi, Federico
Querques, Lea
Introini, Ugo
Souied, Eric H.
Bandello, Francesco
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2016, 36 (12): : S65 - S72
[30] The Impact of miRNAs in Health and Disease of Retinal Pigment Epithelium
Intartaglia, Daniela
Giamundo, Giuliana
Conte, Ivan
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 8

← 1 2 3 4 5 →