Chronic Fatigue and Dysautonomia following COVID-19 Vaccination Is Distinguished from Normal Vaccination Response by Altered Blood Markers

被引：11

作者：

Semmler, Amelie ^{[1
]}

Mundorf, Anna Katharina ^{[1
]}

Kuechler, Anna Sabrina ^{[1
]}

Schulze-Bosse, Karin ^{[1
]}

Heidecke, Harald ^{[2
]}

Schulze-Forster, Kai ^{[2
]}

Schott, Matthias ^{[3
]}

Uhrberg, Markus ^{[4
]}

Weinhold, Sandra ^{[4
]}

Lackner, Karl J. ^{[5
]}

Pawlitzki, Marc ^{[6
]}

Meuth, Sven Guenther ^{[6
]}

Boege, Fritz ^{[1
]}

Ruhrlaender, Jana ^{[7
]}

机构：

[1] Heinrich Heine Univ, Univ Hosp Dusseldorf, Cent Inst Clin Chem & Lab Diagnost, Med Fac, D-40225 Dusseldorf, Germany

[2] Cell Trend GmbH, D-14943 Luckenwalde, Germany

[3] Heinrich Heine Univ, Univ Hosp Dusseldorf, Med Fac, Div Spec Endocrinol, D-40225 Dusseldorf, Germany

[4] Heinrich Heine Univ, Univ Hosp Dusseldorf, Inst Transplantat Diagnost & Cell Therapeut, Med Fac, D-40225 Dusseldorf, Germany

[5] Johannes Gutenberg Univ Mainz, Univ Med Ctr, D-55101 Mainz, Germany

[6] Heinrich Heine Univ, Dept Neurol, D-40225 Dusseldorf, Germany

[7] Selbsthilfegrp Post Vac Syndrom Deutschland e V, D-34121 Kassel, Germany

来源：

VACCINES | 2023年 / 11卷 / 11期

关键词：

post-acute COVID-19 vaccination syndrome; PACVS; G-protein-coupled receptor; receptor antibody; interleukin-6; dysautonomia; chronic fatigue; HUMAN-PAPILLOMAVIRUS VACCINATION; PROTEIN-COUPLED RECEPTORS; SMALL FIBER NEUROPATHY; TACHYCARDIA SYNDROME; ANTIBODIES; AUTOANTIBODIES;

D O I：

10.3390/vaccines11111642

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

SARS-CoV-2 mRNA vaccination can entail chronic fatigue/dysautonomia tentatively termed post-acute COVID-19 vaccination syndrome (PACVS). We explored receptor autoantibodies and interleukin-6 (IL-6) as somatic correlates of PACVS. Blood markers determined before and six months after first-time SARS-CoV-2 vaccination of healthy controls (N = 89; 71 females; mean/median age: 39/49 years) were compared with corresponding values of PACVS-affected persons (N = 191; 159 females; mean/median age: 40/39 years) exhibiting chronic fatigue/dysautonomia (>= three symptoms for >= five months after the last SARS-CoV-2 mRNA vaccination) not due to SARS-CoV-2 infection and/or confounding diseases/medications. Normal vaccination response encompassed decreases in 11 receptor antibodies (by 25-50%, p < 0.0001), increases in two receptor antibodies (by 15-25%, p < 0.0001) and normal IL-6. In PACVS, serological vaccination-response appeared significantly (p < 0.0001) altered, allowing discrimination from normal post-vaccination state (sensitivity = 90%, p < 0.0001) by increased Angiotensin II type 1 receptor antibodies (cut-off <= 10.7 U/mL, ROC-AUC = 0.824 +/- 0.027), decreased alpha-2B adrenergic receptor antibodies (cut-off >= 25.2 U/mL, ROC-AUC = 0.828 +/- 0.025) and increased IL-6 (cut-off <= 2.3 pg/mL, ROC-AUC = 0.850 +/- 0.022). PACVS is thus indicated as a somatic syndrome delineated/detectable by diagnostic blood markers.

引用

页数：16

共 48 条

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